ISOLATION AND CHARACTERIZATION OF A CDNA CLONE ENCODING HUMAN AROMATIC L-AMINO-ACID DECARBOXYLASE
ISOLATION AND CHARACTERIZATION OF A CDNA CLONE ENCODING HUMAN AROMATIC L-AMINO-ACID DECARBOXYLASE
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DOI：
10.1016/0006-291x(89)91772-5
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发表时间：
1989-11-15
影响因子：
3.1
通讯作者：
NAGATSU, T
中科院分区：
文献类型：
--
作者：
ICHINOSE, H;KUROSAWA, Y;NAGATSU, T
The nucleotide sequence of a cDNA clone that includes the entire coding region of human aromatic L-amino acid decarboxylase gene is presented. A human pheochromocytoma cDNA library was screened using an oligonucleotide probe which corresponded to a partial amino acid sequence of the enzyme purified from the human pheochromocytoma. The isolated cDNA clone encoded a protein of 480 amino acids with a calculated molecular mass of 53.9 kDa. The amino acid sequence Asn-Phe-Asn-Pro-His-Lys-Trp around a possible cofactor (pyridoxal phosphate) binding site is identical in human, Drosophila, and pig enzymes.
