Delayed spatial alternation deficits resulting from perinatal PCB exposure in monkeys.
Delayed spatial alternation deficits resulting from perinatal PCB exposure in monkeys.
复制标题
猴子围产期 PCB 暴露导致延迟空间交替缺陷。
DOI：
10.1007/bf00332486
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发表时间：
1988
影响因子：
6.1
通讯作者：
Bowman,RE
中科院分区：
文献类型：
--
作者：
Levin,ED;Schantz,SL;Bowman,RE
在4-6岁时，对在子宫内和出生后4个月的哺乳期内长期接触低水平多氯联苯（PCB）的猴子进行了延迟空间交替（DSA）测试，这是一项空间学习和记忆任务。缺陷的性能准确性检测在两个队列的猴子，其母亲已被喂食2.5 ppm的多氯联苯混合物，Aroclor 1248，在他们的饮食为18个月的时间结束至少12个月前怀孕。这种缺陷在较短的延迟时最为明显，这表明这不是由于记忆障碍，而是由于联想或注意力过程的障碍。一组猴子的母亲被喂食1.0 ppm的多氯联苯混合物Aroclor 1016，也可能出现缺陷。然而，这一组的缺陷不像其他组那么明显。暴露结束后3年多出现多氯联苯引起的认知缺陷，表明低水平围产期多氯联苯暴露存在非常长期的不良后果。
Monkeys exposed to low, chronic levels of polychlorinated biphenyls (PCBs) in utero and during nursing until 4 months after birth were tested at 4–6 years of age on delayed spatial alternation (DSA), a spatial learning and memory task. Deficits in performance accuracy were detected in two cohorts of monkeys whose mothers had been fed 2.5 ppm of the PCB mixture, Aroclor 1248, in their diet for an 18-month period ending at least 12 months prior to pregnancy. The deficit was most apparent at the shorter delays, suggesting that it was not due to memory impairment, but may have been due to impairments in associational or attentional processes. There may also have been a deficit in a group of monkeys whose mothers were fed 1.0 ppm of the PCB mixture, Aroclor 1016. However, the deficit in this group was less pronounced than in the other groups. The appearance of a PCB-induced cognitive deficit more than 3 years after the end of exposure indicated the existence of very long-term adverse consequences of low-level perinatal PCB exposure.