Doxorubicin loading on graphene oxide, iron oxide and gold nanoparticle hybrid
Doxorubicin loading on graphene oxide, iron oxide and gold nanoparticle hybrid
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DOI：
10.1039/c3tb20992j
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发表时间：
2013-01-01
影响因子：
7
通讯作者：
Yigit, Mehmet V.
中科院分区：
文献类型：
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作者：
Balcioglu, Mustafa;Rana, Muhit;Yigit, Mehmet V.
我们报告了一种基于氧化石墨烯的功能杂化材料的简单非共价结构，其中包含金和荧光标记的超顺磁性氧化铁纳米粒子 [GO-MNc(y5.5)-AuNP]。所得的[GO-MNcy(5.5)-AuNP]杂化物表现出各组分的物理性质。磁性纳米颗粒的弛豫度得到改善，cy5.5荧光被完全猝灭，并且在杂化复合物中观察到金纳米颗粒在520 nm处的表面等离子体峰。该混合物在0.32 mg ml(-1)药物浓度下表现出6.05 mg mg(-1)的超高阿霉素负载能力。由于其造影剂成分和抗癌药物负载能力，这种材料可以作为治疗诊断学的有前景的平台。
We report the facile and non-covalent construction of a graphene oxide-based functional hybrid material with gold and fluorescently labeled superparamagnetic iron oxide nanoparticles [GO-MNc(y5.5)-AuNP]. The obtained [GO-MNcy(5.5)-AuNP] hybrid exhibits the physical properties of each component. The relaxivity of the magnetic nanoparticles was improved, cy5.5 fluorescence was completely quenched and the surface plasmon peak of the gold nanoparticles at 520 nm was observed in the hybrid complex. The hybrid exhibits an ultra-high doxorubicin loading capacity of 6.05 mg mg(-1) at 0.32 mg ml(-1) drug concentration. This material could serve as a promising platform for theranostics, due to its contrast agent composition and anticancer drug loading capacity.