Papillomavirus Infectious Pathways: A Comparison of Systems.
Papillomavirus Infectious Pathways: A Comparison of Systems.
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DOI：
10.3390/v7082823
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发表时间：
2015-08-04
期刊：
影响因子：
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通讯作者：
Meyers C
中科院分区：
文献类型：
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作者：
Biryukov J;Meyers C
HPV病毒的生命周期与宿主细胞分化密切相关，导致病毒体在培养物中生长困难。绕过分化上皮的需要的系统已经允许产生重组颗粒，例如病毒样颗粒（VLP）、假病毒体（PsV）和准病毒体（QV）。许多关于HPV生命周期、感染性和结构的研究都是利用重组颗粒进行的。虽然重组颗粒已被证明是无价的，允许HPV领域的快速发展，但重组颗粒和天然病毒体之间存在一些显著差异，并且很少使用天然病毒体进行比较研究以确认结果。这篇评论旨在解决HPV领域关于天然病毒体和重组颗粒的相互矛盾的数据。
The HPV viral lifecycle is tightly linked to the host cell differentiation, causing difficulty in growing virions in culture. A system that bypasses the need for differentiating epithelium has allowed for generation of recombinant particles, such as virus-like particles (VLPs), pseudovirions (PsV), and quasivirions (QV). Much of the research looking at the HPV life cycle, infectivity, and structure has been generated utilizing recombinant particles. While recombinant particles have proven to be invaluable, allowing for a rapid progression of the HPV field, there are some significant differences between recombinant particles and native virions and very few comparative studies using native virions to confirm results are done. This review serves to address the conflicting data in the HPV field regarding native virions and recombinant particles.