Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma
Local elevation of the anti-inflammatory interleukin-10 in the pathogenesis of chronic subdural hematoma
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DOI：
10.1007/s10143-006-0019-7
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发表时间：
2006-07-01
影响因子：
2.8
通讯作者：
Endo, S
中科院分区：
文献类型：
--
作者：
Wada, T;Kuroda, K;Endo, S
我们通过测定血浆和硬膜下液中白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和白细胞介素-10（IL-10）的水平来研究炎症和抗炎细胞因子在慢性硬膜下血肿（CSDH）发病机制中的关系。采用酶联免疫吸附法检测34例慢性硬膜下血肿患者硬膜下液中IL-6、IL-8和IL-10的水平。根据硬膜下积液中IL-10水平将患者分为高IL-10组和低IL-10组。高IL-10组硬膜下液IL-6、IL-8水平明显高于低IL-10组（P < 0.05）。低IL-10组患者的CT扫描显示分离或分层型模式的趋势。
We investigated the relationship between inflammatory and anti-inflammatory cytokines in the pathogenesis of chronic subdural hematoma (CSDH) by measuring the plasma and subdural fluid levels of interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10). The levels of IL-6, IL-8 and IL-10 were measured in the subdural fluid obtained from 34 patients with CSDH, using the enzyme-linked immunosorbent assay. The patients were classified into a high IL-10 group and a low IL-10 group according to the level of IL-10 in their subdural fluid samples. The subdural fluid levels of IL-6 and IL-8 were significantly higher in the high IL-10 group than in the low IL-10 group (P < 0.05). A tendency for the patients in the low IL-10 group to show the separated or layer type of pattern on the CT scans was noted.