Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients
Metastatic spine disease: epidemiology, pathophysiology, and evaluation of patients
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DOI：
10.1016/j.nec.2004.04.018
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发表时间：
2004-10-01
影响因子：
2.6
通讯作者：
Laxton, AW
中科院分区：
文献类型：
--
作者：
Perrin, RG;Laxton, AW
转移性肿瘤是脊柱最常见的肿瘤，是全身性癌症的一种恶性扩展。局部背部或颈部疼痛是最早和最常见的表现，最初常常被认为是“背部或颈部劳损”或“椎间盘突出”。“这是不言自明的，癌症患者新发颈部或背部疼痛窝藏脊柱转移，直到证明否则。疼痛之后是虚弱、麻木和括约肌功能障碍，除非及时治疗，否则所有这些都会无情地发展为完全和不可逆的瘫痪。平片是一种简单而有用的筛查方法。MRI成像是首选的成像方法。经皮影像引导脊柱活检已成为一种有用的测试，以建立一个组织诊断。
Metastatic tumors are the most common neoplasms of the spine and represent an ominous extension of systemic cancer. Local back or neck pain is the earliest and most common presentation and is all too often initially dismissed as "back or neck strain" or "slipped disk." It is axiomatic that a cancer patient with new-onset neck or back pain harbors spinal metastasis until proven otherwise. Pain is followed by weakness, numbness, and sphincter dysfunction, all of which progresses relentlessly to complete and irreversible paralysis unless timely treatment is undertaken. Plain radiographs provide a simple and useful screening test. MRI imaging is the imaging method of choice. Percutaneous image-guided spine biopsy has become a useful test to establish a tissue diagnosis.