Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
Mechanism of Controlled Release of Vancomycin from Crumpled Graphene Oxides
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从皱褶氧化石墨烯中控制释放万古霉素的机制
DOI：
10.1021/acsomega.9b00873
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发表时间：
2019-07-01
期刊：
影响因子：
4.1
通讯作者：
Su, Jiacan
中科院分区：
文献类型：
--
作者：
He, Xing;Zhou, Ziyan;Su, Jiacan
研究了氧化石墨烯（GO）和皱褶氧化石墨烯（CGO）与万古霉素（VAN）的物理和化学相互作用，并提出了可能的加载和释放机制。通过水接触角和ζ电位测量，发现CGO的亲水性和表面电荷有所改善。傅里叶变换红外光谱和x射线光电子能谱证实了VAN通过π -π堆叠和氢键附着在CGO或GO上。CGO-VAN和GO-VAN药物配合物均表现出ph控制释放特性。在CGO-VAN体系中，高负载和延迟释放主要是由于皱褶形态造成的。
The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through π–π stacking and hydrogen bonding. Both CGO–VAN and GO–VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO–VAN system were mainly due to the crumpled morphology.