New structural brain imaging endophenotype in bipolar disorder
New structural brain imaging endophenotype in bipolar disorder
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DOI：
10.1038/mp.2011.3
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发表时间：
2012-04-01
影响因子：
11
通讯作者：
Soares, J. C.
中科院分区：
文献类型：
--
作者：
Matsuo, K.;Kopecek, M.;Soares, J. C.
神经影像学研究提示双相情感障碍（BD）患者存在大脑前边缘结构异常，但很少有研究表明这些异常存在于未受影响但遗传上易受影响的家庭成员中。在这项研究中，我们报告的形态学相关的遗传风险BD使用体素为基础的形态学。对35例BD I型（BD-I）患者和20例BD患者的一级亲属（UAR）及40例健康对照者进行3 T磁共振扫描。在SPM 8（Wellcome Department of Imaging Neuroscience，伦敦，英国）中，使用DARTEL（通过指数李代数的形态解剖配准）进行基于体素的形态测量的图像预处理。全脑分析显示，左侧前额叶和右侧额下回的灰质（GM）体积显示出显着的诊断主效应。多重比较分析显示，BD-I组和UAR组左前岛GM体积均小于健康组，BD-I组右额下回体积小于健康组。对于白色物质（WM）的体积，有一个显着的主效应的诊断额内侧回。UAR受试者与健康受试者相比，右内侧额叶WM体积较小。这些研究结果表明，形态测量大脑异常的前边缘神经基板与BD的家族史，这可能会给深入了解BD的病理生理，并作为一个潜在的候选人的BD的形态学内表型。Molecular Psychiatry（2012）17，412-420; doi：10.1038/mp.2011.3; 2011年2月15日在线发表
Neuroimaging studies suggest anterior-limbic structural brain abnormalities in patients with bipolar disorder (BD), but few studies have shown these abnormalities in unaffected but genetically liable family members. In this study, we report morphometric correlates of genetic risk for BD using voxel-based morphometry. In 35 BD type I (BD-I) patients, 20 unaffected first-degree relatives (UAR) of BD patients and 40 healthy control subjects underwent 3 T magnetic resonance scanner imaging. Preprocessing of images used DARTEL (diffeomorphic anatomical registration through exponentiated lie algebra) for voxel-based morphometry in SPM8 (Wellcome Department of Imaging Neuroscience, London, UK). The whole-brain analysis revealed that the gray matter (GM) volumes of the left anterior insula and right inferior frontal gyrus showed a significant main effect of diagnosis. Multiple comparison analysis showed that the BD-I patients and the UAR subjects had smaller left anterior insular GM volumes compared with the healthy subjects, the BD-I patients had smaller right inferior frontal gyrus compared with the healthy subjects. For white matter (WM) volumes, there was a significant main effect of diagnosis for medial frontal gyrus. The UAR subjects had smaller right medial frontal WM volumes compared with the healthy subjects. These findings suggest that morphometric brain abnormalities of the anterior-limbic neural substrate are associated with family history of BD, which may give insight into the pathophysiology of BD, and be a potential candidate as a morphological endophenotype of BD. Molecular Psychiatry (2012) 17, 412-420; doi: 10.1038/mp.2011.3; published online 15 February 2011