A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release.
A pillararene-based ternary drug-delivery system with photocontrolled anticancer drug release.
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DOI：
10.1002/smll.201402236
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发表时间：
2015-02
期刊：
影响因子：
13.3
通讯作者：
Guocan Yu;Wei Yu;Z. Mao;Changyou Gao;Feihe Huang
中科院分区：
文献类型：
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作者：
Guocan Yu;Wei Yu;Z. Mao;Changyou Gao;Feihe Huang
使用可光降解的抗癌前药（Py-Cbl）、水溶性柱芳烃超分子容器（WP 6）和二嵌段共聚物甲氧基-聚（乙二醇）114 -嵌段-聚（L -赖氨酸盐酸盐）200构建了新型三元药物递送系统（DDS）。该DDS成功地解决了三个重要问题：提高抗癌前药的水溶性;抗癌药物的控制释放;药物释放的准确和定量测量。
A novel ternary drug delivery system (DDS) is constructed using a photodegradable anticancer prodrug (Py-Cbl), a water-soluble pillararene supramolecular container (WP6), and the diblock copolymer methoxy-poly(ethylene glycol)114 -block-poly(L -lysine hydrochloride)200. This DDS successfully addresses three important issues: enhancement of the water solubility of the anticancer prodrug; controlled release of the anticancer drug; accurate and quantitative measurement of the drug release.