Role of sialic acid for platelet life span: exposure of β-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes
Role of sialic acid for platelet life span: exposure of β-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes
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DOI：
10.1182/blood-2009-01-199414
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发表时间：
2009-08-20
期刊：
影响因子：
20.3
通讯作者：
Hoffmeister, Karin M.
中科院分区：
文献类型：
--
作者：
Sorensen, Anne Louise;Rumjantseva, Viktoria;Hoffmeister, Karin M.
虽然表面唾液酸被认为是循环血细胞和糖蛋白存活的关键决定因素，但其在血小板循环寿命中的作用尚未完全阐明。我们表明，血小板减少症的小鼠缺乏的St 3Gal 4唾液酸转移酶基因（St 3Gal-IV-/-小鼠）是由识别的终端半乳糖残基暴露在血小板表面上的唾液酸化的情况下。这导致表达去唾液酸糖蛋白受体的清道夫细胞加速血小板清除，这是最近显示在肺炎链球菌脓毒症期间诱导血小板减少的机制。我们现在确定血小板GPIb α作为ST 3Gal-IV-/-血小板上脱唾液酸糖蛋白受体的主要反受体。此外，我们报告的数据，建立唾液酸化的血管性血友病因子在其功能的重要性。（血。2009; 114：1645-1654）
Although surface sialic acid is considered a key determinant for the survival of circulating blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We show that thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV-/- mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. This results in accelerated platelet clearance by asialoglycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis. We now identify platelet GPIb alpha as a major counterreceptor on ST3Gal-IV-/- platelets for asialoglycoprotein receptors. Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function. (Blood. 2009; 114: 1645-1654)