Coordinated grid and place cell replay during rest
Coordinated grid and place cell replay during rest
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DOI：
10.1038/nn.4291
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发表时间：
2016-06-01
影响因子：
25
通讯作者：
Barry, Caswell
中科院分区：
文献类型：
--
作者：
Olafsdottir, H. Freyja;Carpenter, Francis;Barry, Caswell
海马神经元重放被假设为记忆巩固和导航计划的基础，但网格细胞参与重放的情况尚不清楚。在重放过程中，我们发现网格细胞与位置细胞在空间上是一致的，编码位置相对于海马延迟11毫秒，定向调制的网格细胞和向前重放表现出与海马CA1区的最大一致性。这表明网格细胞参与了空间记忆向新皮层的巩固过程。
Hippocampal replay has been hypothesized to underlie memory consolidation and navigational planning, yet the involvement of grid cells in replay is unknown. During replay we found grid cells to be spatially coherent with place cells, encoding locations 11 ms delayed relative to the hippocampus, with directionally modulated grid cells and forward replay exhibiting the greatest coherence with the CA1 area of the hippocampus. This suggests grid cells are engaged during the consolidation of spatial memories to the neocortex.