Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
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DOI：
10.1016/j.ydbio.2007.03.028
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发表时间：
2007-06-15
影响因子：
2.7
通讯作者：
Aizawa, Shinichi
中科院分区：
文献类型：
--
作者：
Furushima, Kenryo;Yamamoto, Akihito;Aizawa, Shinichi
为了确定小鼠前神经外胚层中的Otx 2靶点，我们确定了一个基因mShisa，它与我们以前报道的爪蟾中的头部诱导物xShisa 1同源。mShisa编码针对Writ和Fgf信号传导的拮抗剂;它像xShisa 1一样自主地抑制这些信号传导。mShisa表达在Otx 2突变内脏内胚层、前中内胚层和前神经外胚层中丢失或大大减少。然而，mShisa突变体在头部发育中没有表现出缺陷。Shisa是由五个亚家族，但正常的头部发育mShisa突变体是不太可能解释的补偿mShisa缺陷由其旁系同源物或已知的Writ拮抗剂在前内脏内胚层和/或前中内胚层。(C)2007年爱思唯尔公司All rights reserved.
In an effort to identify Otx2 targets in mouse anterior neuroectoderm we identified a gene, mShisa, which is homologous to xShisa1 that we previously reported as a head inducer in Xenopus. mShisa encodes an antagonist against both Writ and Fgf signalings; it inhibits these signalings cell-autonomously as xShisa1 does. The mShisa expression is lost or greatly reduced in Otx2 mutant visceral endoderm, anterior mesendoderm and anterior neuroectoderm. However, mShisa mutants exhibited no defects in head development. Shisa is composed of five subfamilies, but normal head development in mShisa mutants is unlikely to be explained in terms of the compensation of mShisa deficiency by its paralogues or by known Writ antagonists in anterior visceral endoderm and/or anterior mesendoderm. (C) 2007 Elsevier Inc. All rights reserved.