Differential Entrainment of Peripheral Clocks in the Rat by Glucocorticoid and Feeding
Differential Entrainment of Peripheral Clocks in the Rat by Glucocorticoid and Feeding
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DOI：
10.1210/en.2011-1794
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发表时间：
2012-05-01
期刊：
影响因子：
4.8
通讯作者：
Shigeyoshi, Yasufumi
中科院分区：
文献类型：
--
作者：
Sujino, Mitsugu;Furukawa, Keiichi;Shigeyoshi, Yasufumi
视交叉上核是主生物钟，并通过各种途径重置外周生物钟。糖皮质激素和每日进食是影响大多数外周生物钟的主要时间线索。然而，最近的研究表明，占主导地位的时间因素不同的器官和组织。在我们目前的研究中，我们揭示了在肝，肾，肺，通过限制喂养（RF）和反相皮质酮（CORT）注射肾上腺切除大鼠外周时钟的夹带属性的差异。发现肾脏和肺中的外周时钟被CORT给药的每日刺激所携带，而与进餐时间无关。相反，观察到肝脏时钟被RF方案所携带，即使每天在反相时给予CORT注射。这些结果表明，糖皮质激素是一个强大的zeitgeber，克服了其他夹带因素调节外周振荡器在肾脏和肺，RF是一个主导的介导的夹带能力的昼夜节律钟在肝脏。（内分泌学153：2277-2286，2012）
The suprachiasmatic nucleus is the master circadian clock and resets the peripheral clocks via various pathways. Glucocorticoids and daily feeding are major time cues for entraining most peripheral clocks. However, recent studies have suggested that the dominant timing factor differs among organs and tissues. In our current study, we reveal differences in the entrainment properties of the peripheral clocks in the liver, kidney, and lung through restricted feeding (RF) and antiphasic corticosterone (CORT) injections in adrenalectomized rats. The peripheral clocks in the kidney and lung were found to be entrained by a daily stimulus from CORT administration, irrespective of the meal time. In contrast, the liver clock was observed to be entrained by an RF regimen, even if daily CORT injections were given at antiphase. These results indicate that glucocorticoids are a strong zeitgeber that overcomes other entrainment factors regulating the peripheral oscillators in the kidney and lung and that RF is a dominant mediator of the entrainment ability of the circadian clock in the liver. (Endocrinology 153: 2277-2286, 2012)