Amyloid deposition after cerebral hypoperfusion: Evidenced on [18F]AV-45 positron emission tomography
Amyloid deposition after cerebral hypoperfusion: Evidenced on [18F]AV-45 positron emission tomography
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DOI：
10.1016/j.jns.2012.04.014
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发表时间：
2012-08-15
影响因子：
4.4
通讯作者：
Lee, Tsong-Hai
中科院分区：
文献类型：
--
作者：
Huang, Kuo-Lun;Lin, Kun-Ju;Lee, Tsong-Hai
动物研究表明，脑灌注不足可能与淀粉样斑块积聚有关。淀粉样斑块已知与痴呆有关，[F-18]AV-45是一种与细胞外斑块结合的正电子发射断层扫描（PET）配体。我们假设脑灌注不足的痴呆患者可能增加了[F-18]AV-45的摄取。本文采用[F-18]AV-45 PET检查5例单侧颈动脉狭窄（CAS）所致脑灌注不足痴呆患者，并与6例老年对照进行比较。以整个小脑为参考区域，建立各感兴趣区域的标准摄取值比（SUVR）。所有受试者均行磁共振成像（MRI）以获取结构信息。痴呆合并单侧CAS患者的整体[F-18]AV-45 SUVR（1.34 +/- 0.06）高于对照组（1.10 +/- 0.04,p = 0.0043），尤其是额叶区、颞叶区、楔前叶区、前扣带区和枕区。统计分布图显示，[F-18]AV-45 SUVR在与CAS侧同侧的额内侧、尾状、丘脑、后扣带、枕部和颞中上区显著增加(p
Animal studies have shown that cerebral hypoperfusion may be associated with amyloid plaque accumulation. Amyloid plaque is known to be associated with dementia and [F-18]AV-45 is a positron emission tomography (PET) ligand that binds to extracelluar plaques. We hypothesized that demented patients with cerebral hypoperfusion may have increased [F-18]AV-45 uptake.Five demented patients with cerebral hypoperfusion due to unilateral carotid artery stenosis (CAS) were examined with [F-18]AV-45 PET, and the results were compared with six elderly controls. The standard uptake value ratio (SUVR) of each region of interest (ROI) was created using whole cerebellum as the reference region. All subjects underwent magnetic resonance imaging (MRI) for obtaining structural information.Patients with dementia and unilateral CAS had a higher global [F-18]AV-45 SUVR (1.34 +/- 0.06) as compared with controls (1.10 +/- 0.04, p = 0.0043), especially over the frontal, temporal, precuneus, anterior cingulate and occipital regions. The statistical distribution maps revealed a significantly increased [F-18]AV-45 SUVR in the medial frontal, caudate, thalamus, posterior cingulate, occipital and middle and superior temporal regions ipsilateral to the side of CAS (p