Comparison of Primary B/NKT Non-Hodgkin Lymphomas in Nasopharynx, Nasal Cavity, and Paranasal Sinuses
Comparison of Primary B/NKT Non-Hodgkin Lymphomas in Nasopharynx, Nasal Cavity, and Paranasal Sinuses
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DOI：
10.1002/ohn.194
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发表时间：
2023-02-08
影响因子：
3.4
通讯作者：
Ren，Jianjun
中科院分区：
文献类型：
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作者：
Peng，Jiajia;Qiu，Jianqing;Ren，Jianjun
我们的目的是比较位于鼻腔（NC）、鼻咽和鼻窦的B细胞（B-NHL）和NKT-细胞非霍奇金淋巴瘤（NKT-NHL）之间的临床和生存差异，它们总是被归类为一种鼻窦类型。研究设计从监测、流行病学、和最终结果（SEER）数据库（1975 - 2017）。设置基于人群的队列研究。方法我们进行了单变量和多变量考克斯回归和Kaplan-Meier分析，分别检查鼻腔、鼻咽和鼻窦B/NKT-NHL的生存结局。结果总体而言，大多数B-NHL病例起源于鼻咽，而大多数NKT-NHL病例发生在鼻腔。值得注意的是，随着时间的推移，所有鼻窦B-NHL病例的癌症特殊生存期（CSS）结局均显著改善，而在每种鼻窦NKT-NHL类型中均未观察到此类改善趋势。此外，年龄增加与B-NHL死亡风险升高相关，尤其是鼻腔（风险比[HR]：3.37），而非NKT-NHL。与B‐NHL相比，NKT‐NHL中较高分期对CSS的不利影响更明显，尤其是在鼻咽部位（HR：5.12）。此外，放疗有利于鼻窦B-NHL和NKT-NHL患者的生存，鼻咽NKT-NHL除外。然而，自2010年以来，化疗仅对副鼻窦B-NHL患者的CSS有益（HR：0.42），而不是其他类型的B/NKT-NHL.ConclusionAlthough B-NHL和NKT-NHL在鼻腔，鼻咽和副鼻窦有相似的解剖位置，其clinicostatistics和diseases有很大不同，应作为不同的疾病进行治疗和研究。
ObjectiveWe aimed to compare clinical and survival differences between B‐cell (B‐NHL) and NKT‐cell non‐Hodgkin lymphomas (NKT‐NHL) located in the nasal cavity (NC), nasopharynx, and paranasal sinuses, which are always categorized as one sinonasal type.Study DesignPatients diagnosed with primary B‐NHL and NKT‐NHL in the nasal cavity, nasopharynx, and paranasal sinuses from Surveillance, Epidemiology, and End Results (SEER) database were included (1975‐2017).SettingPopulation‐based cohort study.MethodsWe conducted univariate and multivariate Cox regressions and Kaplan‐Meier analysis to examine survival outcomes of B/NKT‐NHL in the nasal cavity, nasopharynx, and paranasal sinuses, respectively.ResultsOverall, most B‐NHL cases originated from the nasopharynx, while the majority of NKT‐NHL cases occurred in the nasal cavity. Notably, the cancer‐special survival (CSS) outcomes improved significantly in all sinonasal B‐NHL cases over time, whereas no such improvement trend was observed in each sinonasal NKT‐NHL type. Additionally, increasing age was linked with an elevated risk of death in B‐NHL, particularly in the nasal cavity (Hazard ratio [HR]: 3.37), rather than in NKT‐NHL. Compared with B‐NHL, the adverse effect of a higher stage on CSS was more evident in NKT‐NHL, particularly in its nasopharynx site (HR: 5.12). Furthermore, radiotherapy was beneficial for survival in patients with sinonasal B‐NHL and NKT‐NHL, except in the nasopharynx NKT‐NHL. However, chemotherapy has only been beneficial for CSS in patients with paranasal sinuses B‐NHL (HR: 0.42) since 2010, rather than in other types of B/NKT‐NHL.ConclusionAlthough B‐NHL and NKT‐NHL in the nasal cavity, nasopharynx and paranasal sinuses have similar anatomical locations, their clinicodemographics and prognoses are largely different and should be treated and studied as distinct diseases.