Cancer-specific stress and mood disturbance: implications for symptom perception, quality of life, and immune response in women shortly after diagnosis of breast cancer.
Cancer-specific stress and mood disturbance: implications for symptom perception, quality of life, and immune response in women shortly after diagnosis of breast cancer.
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DOI：
10.5402/2012/608039
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发表时间：
2012-01-01
期刊：
影响因子：
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通讯作者：
McArdle, Traci
中科院分区：
文献类型：
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作者：
Kang, Duck-Hee;Park, Na-Jin;McArdle, Traci
目的.确定乳腺癌诊断后不久女性的癌症特异性压力和情绪障碍水平，并评估其与症状感知、生活质量和免疫反应的相关性。设计描述性和相关性。样品和设置。从多学科乳腺诊所招募了100名新诊断的乳腺癌妇女。方法.在开始癌症辅助治疗之前，使用标准化问卷和已建立的生物测定法收集基线数据。在一天的同一时间采集血样。结果高度的癌症特异性压力与高度的情绪障碍显着相关，而情绪障碍又与高度的症状感知、较差的生活质量以及表明高中性粒细胞和低淋巴细胞的免疫特征相关。结论.高癌症特异性压力和相关的情绪障碍与多种行为，临床和生物学因素表现出广泛的负相关关系。对护理的影响。癌症相关的压力和情绪障碍的常规筛查应纳入所有诊断为癌症的患者的护理实践。考虑到与其他生物行为因素的广泛负面关联，早期识别风险患者并提供和评估压力和情绪管理计划可能会对随后的健康结果产生有益的影响。
Purpose. To determine the levels of cancer-specific stress and mood disturbance in women shortly after diagnosis of breast cancer and to assess their associations with symptom perception, quality of life, and immune response. Design. Descriptive and correlational. Sample and Setting. One hundred women with newly diagnosed breast cancer were recruited from interdisciplinary breast clinics. Methods. Baseline data were collected using standardized questionnaires and established bioassay prior to the initiation of cancer adjuvant therapy. Blood samples were collected about the same time of day. Results. High cancer-specific stress was significantly correlated with high mood disturbance, which, in turn, was correlated with high symptom perception, poor quality of life, and an immune profile indicating high neutrophils and low lymphocytes. Conclusions. High cancer-specific stress and related mood disturbance show extensive negative relationships with multiple behavioral, clinical, and biological factors. Implications for Nursing. Routine screening for cancer-related stress and mood disturbance should be incorporated into nursing practice for all patients diagnosed with cancer. Given broad negative associations with other biobehavioral factors, early identification of patients at risk and provision and evaluation of stress and mood management programs may have a beneficial effect on subsequent health outcomes over time.