Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?
Antiviral TRIMs: friend or foe in autoimmune and autoinflammatory disease?
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抗病毒 TRIMs：自身免疫和自身炎症疾病中的敌还是友？
DOI：
10.1038/nri3043
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发表时间：
2011-09-01
影响因子：
100.3
通讯作者：
Higgs, Rowan
中科院分区：
文献类型：
--
作者：
Jefferies, Caroline;Wynne, Claire;Higgs, Rowan
广泛的临床和实验观察支持病毒传感系统通过其驱动促炎细胞因子和干扰素产生的能力促进自身免疫性和自体炎性疾病的发展的概念。最近，含有三个基序的蛋白(TRIMs)在抗病毒免疫中发挥了关键作用--要么作为病毒限制因子，要么作为病毒RNA和DNA传感器下游通路的调节因子，以及炎症体。鉴于它们参与了这些途径，我们认为TRIM蛋白有助于自身免疫和自体炎症条件的发展和病理，从而使它们成为潜在的治疗操作的新靶点。
The concept that viral sensing systems, via their ability to drive pro-inflammatory cytokine and interferon production, contribute to the development of autoimmune and autoinflammatory disease is supported by a wide range of clinical and experimental observations. Recently, the tripartite motif-containing proteins (TRIMs) have emerged as having key roles in antiviral immunity - either as viral restriction factors or as regulators of pathways downstream of viral RNA and DNA sensors, and the inflammasome. Given their involvement in these pathways, we propose that TRIM proteins contribute to the development and pathology of autoimmune and autoinflammatory conditions, thus making them potential novel targets for therapeutic manipulation.