What we have learned about colonic motility: normal and disturbed
What we have learned about colonic motility: normal and disturbed
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DOI：
10.1097/mog.0b013e328332c977
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发表时间：
2010-01-01
影响因子：
2.5
通讯作者：
Quigley, Eamonn M. M.
中科院分区：
文献类型：
--
作者：
Quigley, Eamonn M. M.
结肠运动和感觉功能障碍在儿童和成人中很常见，给诊断和治疗带来了重大挑战；因此，本综述的目的是批判性地评估有关该主题的最新文献。在超微结构、分子和电生理水平上，对产生和控制结肠运动的肌肉、神经和间质细胞的正常功能的理解取得了相当大的进展。此外，这些细胞类型的异常，特别是Cajal间质细胞的异常，已经在许多疾病状态中被发现。在临床实践中，结肠运动和感觉功能的测试仍然是一个挑战，部分原因不仅在于进入器官时出现的技术问题，还在于其生理学的内在变异性。对于治疗结肠运动紊乱的进展来说，这并不是一个吉利的时期；新的药物或“旧”药物的新应用继续被探索，更多的创新方法，如基于油的神经刺激和细胞疗法。在结肠运动障碍的基本病理生理方面已经取得了长足的进展；临床诊断和治疗继续落后。
Purpose of reviewDisorders of colonic motor and sensory function are common among children and adults and pose significant diagnostic and therapeutic challenges; the purpose of this review, therefore, was to critically assess the recent literature on this topic.Recent findingsConsiderable progress has been made at the ultrastructural, molecular and electrophysiological level in understanding the normal functions of the muscles, nerves and interstitial cells that generate and control colonic motility. Furthermore, abnormalities in these cell types and in the interstitial cells of Cajal, in particular, have been identified in a number of disease states. Testing of colonic motor and sensory function in clinical practice continues to be a challenge due, in part, not only to the technical issues presented by accessing the organ but also to the intrinsic variability of its physiology. These have not been auspicious times for advances in the therapy of disturbed colonic motility; new agents or new applications for 'old' agents continue to be explored as are more innovative approaches such as those based oil neural stimulation and cell therapy.SummaryConsiderable progress has been made in understanding the basic pathophysiology of colonic dysmotility; clinical diagnostics and therapeutics continue to lag behind.