Antimicrobial Activity of ε-Poly-L-lysine after Forming a Water-Insoluble Complex with an Anionic Surfactant
Antimicrobial Activity of ε-Poly-L-lysine after Forming a Water-Insoluble Complex with an Anionic Surfactant
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DOI：
10.1021/acs.biomac.7b00109
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发表时间：
2017-04-01
影响因子：
6.2
通讯作者：
Katano, Hajime
中科院分区：
文献类型：
--
作者：
Ushimaru, Kazunori;Hamano, Yoshimitsu;Katano, Hajime
ε-聚-L-赖氨酸（ε-Poly-L-Lysine，s-PL）是自然界中存在的少数几种均聚氨基酸之一。具有多个氨基的ε-PL高度溶于水，在水中形成抗微生物聚阳离子链（PLn+）。尽管高水溶性对于epsilon-PL作为食品防腐剂的用途是有利的，但它限制了epsilon-PL作为生物聚合物塑料的适用性。在这里，我们报告的制备和可用性的水不溶性络合物形成的PLN+和阴离子表面活性剂，双（2-乙基己基）磺基琥珀酸酯（BEHS-，也被商业化为AOT）阴离子。的PLn+/BEHS-复合物，这是可溶于有机溶剂，被成功地用作涂层材料的醋酸纤维素膜，以创建一个防水的抗菌膜。此外，热塑性PLn+/BEHS-复合物能够通过加热与聚丙烯均匀混合，从而产生表现出抗微生物活性的材料。
epsilon-Poly-L-lysine (s-PL) is one of the few homopoly(amino-acid)s occurring in nature. epsilon-PL, which possesses multiple amino groups, is highly soluble in water, where it forms the antimicrobial polycationic chain (PLn+). Although the high water-solubility is advantageous for the use of epsilon-PL as a food preservative, it has limited the applicability of epsilon-PL as a biopolymer plastic. Here, we report on the preparation and availability of a water-insoluble complex formed with PLn+ and an anionic surfactant, bis(2-ethylhexyl) sulfosuccinate (BEHS-, is also commercialized as AOT) anion. The PLn+/BEHS--complex, which is soluble in organic solvents, was successfully used as a coating material for a cellulose acetate membrane to create a water-resistant antimicrobial membrane. In addition, the thermoplastic PLn+/BEHS--complex was able to be uniformly mixed with polypropylene by heating, resulting in materials exhibiting antimicrobial activities.