A reaction for sp3-sp3 C-C bond formation via cooperation of Lewis acid-promoted/Rh-catalyzed C-H bond activation
A reaction for sp3-sp3 C-C bond formation via cooperation of Lewis acid-promoted/Rh-catalyzed C-H bond activation
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DOI：
10.1021/ja0528331
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发表时间：
2005-08-10
影响因子：
15
通讯作者：
Xia, WJ
中科院分区：
文献类型：
--
作者：
Shi, L;Tu, YQ;Xia, WJ
研究了一种新的脂肪伯醇与烯烃间形成sp3− sp 3C-C键的方法，该方法使用RhCl（PPh 3）3（cat.）本文首次报道了BF_3·OEt_2（2.5equiv）/BuBr（0.5equiv）/甲苯体系，该体系在有机合成，特别是仲醇合成中具有重要的应用价值。最重要的方面是发现在刘易斯酸促进的条件下，铑催化的醇的C-H键活化是可行的。
A new method for intermolecular sp3−sp3C−C bond formation between primary aliphatic alcohol and olefin by use of a RhCl(PPh3)3(cat.)/BF3·OEt2(2.5 equiv)/BuBr (0.5 equiv)/toluene system was first disclosed, which possessed quite significant utilities for organic synthesis, especially for that of secondary alcohols. The most significant aspect is the discovery that rhodium-catalyzed C−H bond activation of alcohols is feasible under Lewis acid-promoted conditions.