Nanomaterials and Aging.
Nanomaterials and Aging.
复制标题
纳米材料与老化。
DOI：
10.2174/1574888x15666200422103916
复制
发表时间：
2020-04
影响因子：
2.7
通讯作者：
Cai Xiaoxiao
中科院分区：
文献类型：
--
作者：
Mao Chen-Chen;Cai Xiaoxiao
如今，随着老龄化人口比例的不断提高，越来越多的老年人患有与老龄化相关的疾病。有证据表明，衰老可能是基因调控的结果。即使老龄化不可避免，延长健康老龄化的时间，延缓老龄相关疾病的进展和发病率，也可以极大地缓解个人和社会的压力。如今，材料领域对老化的研究和探索越来越多。在这里，我们粗略地总结了近年来在纳米材料领域中关于老化的研究。一些纳米材料，如二氧化硅纳米管和碳纳米管，可能会由于老化而对细胞造成损害。其他具有还原性能的纳米材料，如富勒烯和金属基纳米材料，由于其优良的还原性能，可以在一定程度上保护人体免受ROS等内源性和外源性有害物质的伤害。另一种新型的核酸纳米材料，四面体骨架核酸，并不局限于避免细胞损伤。它选择性地清除组织中现有的衰老细胞，这种作用也避免了衰老细胞向周围分泌衰老相关的分泌表型而引起的慢性炎症环境。我们认为，纳米材料领域的潜力是巨大的，今天的研究成果只是冰山一角。在老龄化领域，纳米材料仍有很大的开发空间。
Nowadays, with the increasing proportion of the aging population, more and more elderly people suffer from aging-related diseases. Evidences said that aging may be the result of genetic regulation. Even if aging is inevitable, prolonging the time of healthy aging, delaying the progression of aging-related diseases and the incidence of morbidity can greatly alleviate the pressure on individuals and society. Today, the research and exploration of aging in the field of materials is increasing. Here, we have a rough summary of recent researches of aging in the field of nanomaterials. Some nanomaterials such as silica NMs and carbon nanotubes can cause damage to the cells, which may due to aging. Other nanomaterials such as Fullerenes and metal based nanomaterials with reducing properties can protect the body from endogenous and exogenous harmful substances such as ROS to some extent by virtue of their excellent reducing properties. Another new type of nucleic acid nanomaterial, Tetrahedral framework nucleic acids, is not limited to avoiding cell damage. It selectively clearance existing senescent cells in the tissue, and this effect also avoids the chronic inflammatory environment caused by senescent cells secreting senescence-associated secretory phenotype to the surroundings. We believe that the potential in the field of nanomaterials is enormous, and today's research results are just the tip of the iceberg. There are still a lot of space of nanomaterials to explore in the aging field.