Expression of blood-group-related antigens in carcinoma in situ of the urinary bladder.
Expression of blood-group-related antigens in carcinoma in situ of the urinary bladder.
复制标题
膀胱原位癌中血型相关抗原的表达。
DOI：
10.1002/1097-0142(19850815)56:4
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发表时间：
1985
期刊：
影响因子：
6.2
通讯作者：
Weinstein,RS
中科院分区：
文献类型：
--
作者：
Coon,JS;McCall,A;Miller3rd,AW;Farrow,GM;Weinstein,RS
应用免疫组织化学技术，对9例膀胱广泛癌原位癌(CIS)组织和组织学良性上皮组织中的上皮性ABH血型抗原和T(Thomsen-Friedenreich)抗原的表达进行了定量研究。血管内皮细胞ABH染色显示顺应区ABH和T抗原均有异常表达，血管构筑独特。组织学上的正常上皮通常抗原性正常，但偶尔表现出ABH或T抗原的异常。在组织学上不典型的上皮中，抗原的表达是不同的，显著的节段显示ABH或T抗原的异常，有时两种抗原标记都异常。据推测，组织学上是良性的，但抗原性异常，上皮细胞可能代表低级别的膀胱癌。评估膀胱扁平非典型上皮中血型相关抗原的表达可能有助于预测这些病变的生物学潜力。
Expression of epithelial ABH blood group antigens and the T (Thomsen‐Friedenreich)‐antigen was quantitatively studied by immunoperoxidase techniques in nine cystectomy specimens containing extensive carcinomain situ(CIS), and also histologically benign epithelium. CIS areas typically showed abnormal expression of both ABH and T‐antigens and a distinctive vascular architecture, revealed by endothelial ABH staining. Histologically normal epithelium generally was antigenically normal, but occasionally showed abnormalities of either ABH or T‐antigens. Antigen expression was variable in histologically atypical epithelium, with significant segments showing abnormalities of either ABH or T‐antigen, and sometimes of both antigenic markers. It is postulated that histologically benign, but antigenically abnormal, epithelium may represent low‐grade CIS of the urinary bladder. Assessment of blood‐group‐related antigen expression in flat atypical epithelium of the urinary bladder may be useful for predicting the biologic potential of these lesions.