Fetal hypoxia insults and patterns of brain injury: insights from animal models.

Fetal hypoxia insults and patterns of brain injury: insights from animal models.
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DOI:
10.1016/j.clp.2009.06.007
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发表时间:
2009-09
影响因子:
2.1
通讯作者:
Bennet L
Bennet L
中科院分区:
医学4区
文献类型:
--
作者:
Gunn AJ;Bennet L

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围产期缺氧缺血的结果是高度可变的,仅与氧债的“严重程度”有非常广泛的关系,如外周基底缺损和损伤风险。本文综述了窒息性损伤的病理生理学。我们剖析了改变损伤风险的多种因素,包括损伤的深度(“严重程度”)、持续时间和重复、胎儿的成熟度和状况、先前存在的缺氧、暴露于高温和感染/炎症。
The outcome of perinatal hypoxia-ischemia is highly variable, with only a very broad relationship to the ‘severity’ of oxygen debt as shown by peripheral base deficit and the risk of damage. The present review examines the pathophysiology of asphyxial injury. We dissect the multiple factors that modify the risk of injury, including the depth (‘severity’), duration, and repetition of the insult, the maturity, and condition of the fetus, pre-existing hypoxia, and exposure to pyrexia and infection/inflammation.
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