Fetal hypoxia insults and patterns of brain injury: insights from animal models.
Fetal hypoxia insults and patterns of brain injury: insights from animal models.
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DOI:
10.1016/j.clp.2009.06.007
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发表时间:
2009-09
影响因子:
2.1
通讯作者:
Bennet L
中科院分区:
文献类型:
--
作者:
Gunn AJ;Bennet L
The outcome of perinatal hypoxia-ischemia is highly variable, with only a very broad relationship to the ‘severity’ of oxygen debt as shown by peripheral base deficit and the risk of damage. The present review examines the pathophysiology of asphyxial injury. We dissect the multiple factors that modify the risk of injury, including the depth (‘severity’), duration, and repetition of the insult, the maturity, and condition of the fetus, pre-existing hypoxia, and exposure to pyrexia and infection/inflammation.
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影响因子:
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