An interactive meta-analysis of MRI biomarkers of myelin.
An interactive meta-analysis of MRI biomarkers of myelin.
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DOI：
10.7554/elife.61523
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发表时间：
2020-10-21
期刊：
影响因子：
7.7
通讯作者：
Stikov N
中科院分区：
文献类型：
--
作者：
Mancini M;Karakuzu A;Cohen-Adad J;Cercignani M;Nichols TE;Stikov N
已经提出了几种 MRI 测量方法作为髓磷脂的体内生物标志物，每种方法的应用范围从可塑性到病理学。尽管这些髓磷脂敏感模式已经可用，但特异性和敏感性一直是一个讨论问题。关于哪种 MRI 测量最适合量化髓磷脂的争论仍在继续。在这项研究中，我们对已发表的定量验证研究进行了系统回顾，以阐明这些测量与基础组织学相比有多么不同。我们应用荟萃分析工具、控制研究样本大小并使用交互式可视化分析了 43 项研究的结果 (https://neurolibre.github.io/myelin-meta-analysis)。我们报告了确定系数的总体估计值和预测区间，并发现基于 MT 和松弛测量法的测量与髓磷脂含量具有最高的相关性。我们还展示了哪些测量是有差异的，哪些测量在与组织学的关系方面没有统计差异。
Several MRI measures have been proposed as in vivo biomarkers of myelin, each with applications ranging from plasticity to pathology. Despite the availability of these myelin-sensitive modalities, specificity and sensitivity have been a matter of discussion. Debate about which MRI measure is the most suitable for quantifying myelin is still ongoing. In this study, we performed a systematic review of published quantitative validation studies to clarify how different these measures are when compared to the underlying histology. We analyzed the results from 43 studies applying meta-analysis tools, controlling for study sample size and using interactive visualization (https://neurolibre.github.io/myelin-meta-analysis). We report the overall estimates and the prediction intervals for the coefficient of determination and find that MT and relaxometry-based measures exhibit the highest correlations with myelin content. We also show which measures are, and which measures are not statistically different regarding their relationship with histology.