Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: The Chicago health, aging, and social relations study
Psychosocial and behavioral predictors of inflammation in middle-aged and older adults: The Chicago health, aging, and social relations study
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DOI：
10.1097/01.psy.0000221371.43607.64
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发表时间：
2006-05-01
影响因子：
3.3
通讯作者：
Cacioppo, John T.
中科院分区：
文献类型：
--
作者：
McDade, Thomas W.;Hawkley, Louise C.;Cacioppo, John T.
目的：C反应蛋白(CRP)是心血管疾病(CVD)的重要预测因子，慢性炎症可能是应激影响疾病风险的机制之一。我们调查了以人群为基础的中老年人样本中，行为和心理社会因素对C反应蛋白浓度变化的影响。方法：采用高灵敏度的酶联免疫吸附试验(EL ISA)检测188例52~70岁老年人血标本中的CRP浓度。在采集血液样本的同一天收集人口统计数据(性别、种族、社会经济状况)、人体测量数据(身高、体重、腰围、体脂百分比)、行为数据(饮酒、吸烟、睡眠质量、饮食质量)和心理社会数据(感受到的压力、慢性压力、抑郁症状、孤独、感受到的社会支持)。前一年收集的心理社会变量也被用来调查变化的心理社会环境的影响。在一系列嵌套多变量回归模型中检验对数变换后的CRP浓度。结果：非裔美国人和女性参与者的CRP浓度较高，受教育程度较低的人也是如此。然而，在添加了行为和心理社会变量后，种族差异消失了。腰围、睡眠潜伏期、吸烟和感觉到的压力与C反应蛋白浓度升高独立相关。结论：在以人群为基础的样本中，心理社会压力和健康行为是炎症活动的重要预测因子，在未来的炎症和心血管疾病研究中应予以考虑。
Objective: C-reactive protein (CRP) is emerging as an important predictor of cardiovascular disease (CVD), and chronic inflammation may be a mechanism through which stress affects disease risk. We investigated the contribution of behavioral and psychosocial factors to variation in CRP concentrations in a population-based sample of middle-aged and older adults. Methods: A high sensitivity enzyme-linked immunosorbent assay (ELISA) validated for use with dried blood spot samples was used to determine CRP concentrations in a representative sample of 188 52- to 70-year-olds. Demographic (gender, ethnicity, socioeconomic status), anthropometric (height, weight, waist circumference, percent body fat), behavioral (alcohol consumption, smoking, sleep quality, dietary quality), and psychosocial data (perceived stress, chronic stress, depressive symptoms, loneliness, perceived social support) were collected on the same day as blood samples. Psychosocial variables collected the year before were also used to investigate the impact of changing psychosocial environments. Log-transformed CRP concentrations were examined in a series of nested multivariate regression models. Results: African American and female participants were found to have higher CRP concentrations, as did individuals with lower levels of education. However, ethnic differences disappeared after the addition of behavioral and psychosocial variables. Waist circumference, latency to sleep, smoking, and perceived stress were independently associated with increased concentrations of CRP. Conclusions: Psychosocial stress, as well as health behaviors, are important predictors of inflammatory activity in a population-based sample and should be considered in future research on inflammation and CVD.