Improving Oxygenator Performance Using Computational Simulation and Flow Field-Based Parameters
Improving Oxygenator Performance Using Computational Simulation and Flow Field-Based Parameters
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DOI：
10.1111/j.1525-1594.2010.01157.x
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发表时间：
2010-11-01
影响因子：
2.4
通讯作者：
Steinseifer, Ulrich
中科院分区：
文献类型：
--
作者：
Graefe, Roland;Borchardt, Ralf;Steinseifer, Ulrich
氧合器开发的当前目标是减少外部表面接触面积、血栓形成、溶血和预充体积。为了实现这些目标，并提供一个有利的浓度梯度的气体交换整个纤维束，本研究试图找到一个优化的入口和出口端口的几何形状，以引导目前正在开发的六边形氧合器的流量。从数值流动模拟得到的参数允许自动定量评价流量分配板的几何形状变化。这导致了对流动质量的实际评估。通过与流动可视化结果的比较，定性地验证了结果。研究了两个参数，第一个基于速度分布，第二个从代表红细胞的无质量颗粒的停留时间计算。这两种方法显示出显着的潜力，以改善纤维束中的流型，基于高达66%的参数之一。计算流体动力学与参数化相结合被证明是快速改进氧合器设计的有力工具。
Current goals in the development of oxygenators are to reduce extrinsic surface contact area, thrombus formation, hemolysis, and priming volume. To achieve these goals and provide a favorable concentration gradient for the gas exchange throughout the fiber bundle, this study attempts to find an optimized inlet and outlet port geometry to guide the flow of a hexagonal-shaped oxygenator currently under development. Parameters derived from numerical flow simulations allowed an automated quantitative evaluation of geometry changes of flow distribution plates. This led to a practical assessment of the quality of the flow. The results were validated qualitatively by comparison to flow visualization results. Two parameters were investigated, the first based on the velocity distribution and the second calculated from the residence time of massless particles representing erythrocytes. Both approaches showed significant potential to improve the flow pattern in the fiber bundle, based on one of the parameters of up to 66%. Computational fluid dynamics combined with a parameterization proved to be a powerful tool to quickly improve oxygenator designs.