A Systems View of the Heparan Sulfate Interactome
A Systems View of the Heparan Sulfate Interactome
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DOI：
10.1369/0022155420988661
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发表时间：
2021-02
影响因子：
3.2
通讯作者：
Alejandro Gómez Toledo;James T. Sorrentino;Daniel R Sandoval;J. Malmström;N. Lewis;J. Esko
中科院分区：
文献类型：
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作者：
Alejandro Gómez Toledo;James T. Sorrentino;Daniel R Sandoval;J. Malmström;N. Lewis;J. Esko
硫酸乙酰肝素蛋白聚糖由一个或多个共价连接硫酸乙酰肝素糖胺聚糖链修饰的小家族蛋白质组成。这些链具有复杂的结构模式，基于硫酸盐基团和尿酸外显体的位置，这决定了它们能够结合大量硫酸肝素结合蛋白，包括细胞外基质蛋白、生长因子和形态因子、细胞因子和趋化因子、载脂蛋白和脂肪酶、粘附和生长因子受体，以及补体和凝血系统的成分。这篇综述强调了所谓的“硫酸肝素相互作用组”表征的最新进展，主要关注作为发现和表征该亚蛋白质组的工具的全系统策略。此外，我们整理了迄今为止文献中报道的所有硫酸肝素结合蛋白，并通过网络方法将它们分为几个主要的功能类。
Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains. These chains have intricate structural patterns based on the position of sulfate groups and uronic acid epimers, which dictate their ability to engage a large repertoire of heparan sulfate–binding proteins, including extracellular matrix proteins, growth factors and morphogens, cytokines and chemokines, apolipoproteins and lipases, adhesion and growth factor receptors, and components of the complement and coagulation system. This review highlights recent progress in the characterization of the so-called “heparan sulfate interactome,” with a major focus on systems-wide strategies as a tool for discovery and characterization of this subproteome. In addition, we compiled all heparan sulfate–binding proteins reported in the literature to date and grouped them into a few major functional classes by applying a networking approach.