Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP
Clinical and electrophysiologic correlates of IVIg responsiveness in CIDP
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DOI：
10.1212/01.wnl.0000158680.89323.f8
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发表时间：
2005-04-26
期刊：
影响因子：
9.9
通讯作者：
Sobue, G
中科院分区：
文献类型：
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作者：
Iijima, M;Yamamoto, M;Sobue, G
为了确定慢性炎症性脱髓鞘性多发性神经病（CIDP）中与IV免疫球蛋白（IVIg）反应性相关的临床和电生理特征，作者对312例CIDP患者（199例反应者和113例无反应者）进行了一项多中心研究。肌肉萎缩和复合肌肉动作电位降低在IVIg无应答者中明显。男性、病程较长和症状进展缓慢也与IVIg无反应性相关。提示周围神经轴突功能障碍的特征表明CIDP中IVIg无反应。
To identify clinical and electrophysiologic features related to IV immunoglobulin (IVIg) responsiveness in chronic inflammatory demyelinating polyneuropathy ( CIDP), the authors conducted a multicenter study on 312 patients with CIDP ( 199 responders and 113 nonresponders). Muscle atrophy and decreased compound muscle action potential were pronounced in nonresponders of IVIg. Male gender, longer disease duration, and slow progression of symptoms were also associated with IVIg unresponsiveness. Features suggesting axonal dysfunction in peripheral nerves indicated IVIg unresponsiveness in CIDP.