Alpha-interferon therapy in a case of probable progressive multifocal leukoencephalopathy.
Alpha-interferon therapy in a case of probable progressive multifocal leukoencephalopathy.
复制标题
α-干扰素治疗可能的进行性多灶性白质脑病病例。
作者：
C. Colosimo;P. Lebon;M. Martelli;F. Tumminelli;F. Mandelli
一名63岁的男性非霍奇金淋巴瘤完全缓解，根据临床表现和磁共振成像诊断为可能的进行性多灶性白质脑病（PML）。在引入肌内α-干扰素治疗后，他的神经系统状态和MRI结果显示出明显的改善。首次症状发作后18个月，患者已从失语症和运动障碍中显著恢复，仅表现出轻度注意力缺陷。
Probable progressive multifocal leukoencephalopathy (PML) was diagnosed on the basis of clinical picture and magnetic resonance imaging in a 63-year-old man with a complete remission of a non-Hodgkin's lymphoma. After the introduction of intramuscular alpha-interferon therapy, his neurological state and MRI findings showed a clear improvement. Eighteen months after the onset of first symptoms the patient has significantly recovered from both aphasia and motor impairment, and shows only a mild attentional deficit.