Effects of long-term physical exercise on skeletal muscles in senescence-accelerated mice (SAMP8)
Effects of long-term physical exercise on skeletal muscles in senescence-accelerated mice (SAMP8)
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DOI：
10.1080/09168451.2018.1547625
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发表时间：
2019-03
期刊：
影响因子：
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通讯作者：
Kaho Takigawa;Rintaro Matsuda;Ran Uchitomi;Takumi Onishi;Yukino Hatazawa;Yasutomi Kamei
中科院分区：
文献类型：
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作者：
Kaho Takigawa;Rintaro Matsuda;Ran Uchitomi;Takumi Onishi;Yukino Hatazawa;Yasutomi Kamei
我们使用衰老加速倾向小鼠（SAMP8）模型研究了长期运动对预防肌肉减少症的影响。小鼠被安置在一个轮笼中25周，以增加自愿运动。在第23周，使用跑步机检查耐力跑步能力。在跑步机跑步测试中，轮笼组耐力跑能力增加，这表明与衰老相关的肌肉功能丧失可以通过长期运动得到恢复。小鼠被处死，微阵列分析显示，参与蛋白质合成和降解的基因在轮笼组骨骼肌中上调，表明蛋白质周转加快。使用轮笼后，全身和脂肪组织重量下降。因此，长期自发的体育锻炼可能有助于从衰老相关的肌肉减少症（肌肉功能丧失）和肥胖中恢复过来。老年相关性肌肉减少症可通过长期运动恢复。
ABSTRACT We examined the effect of long-term exercise on the prevention of sarcopenia using a senescence-accelerated-prone mice (SAMP8) model. Mice were housed in a wheel cage for 25 weeks to increase voluntary exercise. At week 23, endurance running capacity was examined using a treadmill. In a treadmill running test, the wheel cage group had increased endurance running capacity, which suggests that aging-related loss of muscle function was recovered by long-term exercise. Mice were sacrificed and microarray analysis revealed that genes involved in protein synthesis and degradation were upregulated in the skeletal muscles of the wheel cage group, suggesting accelerated protein turnover. Total body and adipose tissue weights decreased following the use of the wheel cage. Thus, long-term, spontaneous physical exercise may assist in recovering from aging-related sarcopenia (loss of muscle function) and obesity. Graphical Abstract Aging-related sarcopenia was recovered by long-term exercise.