Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion.
Derepression of a neuronal inhibitor due to miRNA dysregulation in a schizophrenia-related microdeletion.
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DOI：
10.1016/j.cell.2012.11.052
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发表时间：
2013-01-17
期刊：
影响因子：
64.5
通讯作者：
Gogos JA
中科院分区：
文献类型：
--
作者：
Xu B;Hsu PK;Stark KL;Karayiorgou M;Gogos JA
22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A+/− mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain microRNAs. Here we show a drastic reduction of miR-185, which resides within the 22q11.2 locus, to levels more than expected by a hemizygous deletion and demonstrate that this reduction alters dendritic and spine development. miR-185 represses, through an evolutionary conserved target site, a previously unknown inhibitor of these processes that resides in the Golgi apparatus and shows higher prenatal brain expression. Sustained derepression of this inhibitor after birth represents the most robust transcriptional disturbance in the brains of Df(16)A+/− mice and results in structural alterations in the hippocampus. Reduction of miR-185 also has milder age and region-specific effects on the expression of a group of Golgi-related genes. Our findings illuminate the contribution of microRNAs in psychiatric disorders and cognitive dysfunction.
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影响因子：
64.8
作者：
Baek, Daehyun;Villen, Judit;Shin, Chanseok;Camargo, Fernando D.;Gygi, Steven P.;Bartel, David P.
通讯作者：
Bartel, David P.
影响因子：
25
作者：
Mukai, Jun;Dhilla, Alefiya;Drew, Liam J.;Stark, Kimberly L.;Cao, Luxiang;MacDermott, Amy B.;Karayiorgou, Maria;Gogos, Joseph A.
通讯作者：
Gogos, Joseph A.
DOI：
10.1083/jcb.131.6.1715
发表时间：
1995-12
期刊：
The Journal of cell biology
影响因子：
--
作者：
Nakamura N;Rabouille C;Watson R;Nilsson T;Hui N;Slusarewicz P;Kreis TE;Warren G
通讯作者：
Warren G
影响因子：
16.2
作者：
Horton, AC;Rácz, B;Ehlers, MD
通讯作者：
Ehlers, MD
影响因子：
10.6
作者：
Moreau, Michael P.;Bruse, Shannon E.;David-Rus, Richard;Buyske, Steven;Brzustowicz, Linda M.
通讯作者：
Brzustowicz, Linda M.