Treatment of Cerebral Vasospasm with Intra-arterial Fasudil Hydrochloride
Treatment of Cerebral Vasospasm with Intra-arterial Fasudil Hydrochloride
复制标题
动脉注射盐酸法舒地尔治疗脑血管痉挛
DOI：
10.1227/01.neu.0000147975.24556.bc
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发表时间：
2005
期刊：
影响因子：
4.8
通讯作者：
E. Kohmura
中科院分区：
文献类型：
--
作者：
Kazuhiro Tanaka;H. Minami;Masaaki Kota;K. Kuwamura;E. Kohmura
目的：症状性脑血管痉挛是蛛网膜下腔出血患者致残和死亡的主要原因。本研究的目的是确定动脉内灌注（IAF）盐酸法舒地尔治疗症状性血管痉挛在神经功能改善和脑血管造影特征方面的疗效。方法：连续23例患者接受IAF治疗蛛网膜下腔出血后症状性血管痉挛。在IAF治疗前后评估血管造影血管痉挛。在IAF治疗后24 h内评价即刻临床疗效，并在发病后3个月采用格拉斯哥预后量表评价晚期临床预后。结果：23名患者（16名女性，7名男性）进行了34次IAF治疗。在所有情况下均观察到血管造影改善（100%），在15种情况下观察到即刻临床改善（44.1%）。3个月随访时，15例患者（65.2%）在格拉斯哥结局量表上显示良好恢复或中度残疾。结论：IAF治疗可有效扩张痉挛性动脉，约一半的盐酸法舒地尔输注液可观察到临床改善。提示IAF治疗蛛网膜下腔出血后症状性脑血管痉挛安全有效。
OBJECTIVE:Symptomatic cerebral vasospasm is a major cause of disability and death in patients with aneurysmal subarachnoid hemorrhage. The purpose of this study was to determine the efficacy of intra-arterial infusion (IAF) of fasudil hydrochloride for symptomatic vasospasm in terms of neurological improvement and the angiographic features of cerebral vessels. METHODS:A consecutive series of 23 patients underwent IAF therapy for the treatment of symptomatic vasospasm after subarachnoid hemorrhage. Angiographic vasospasm was assessed before and after the IAF treatment. Immediate clinical effect was assessed within 24 hours after the IAF treatment, and the Glasgow Outcome Scale was used to evaluate late clinical outcome at 3 months after the onset. RESULTS:IAF treatment was performed on 34 occasions for 23 patients (16 women, 7 men). Angiographic improvement was observed on all occasions (100%), and immediate clinical improvement was observed on 15 occasions (44.1%). At 3-month follow-up, 15 patients (65.2%) showed good recovery or moderate disability on the Glasgow Outcome Scale. CONCLUSION:IAF therapy was effective in dilating spastic arteries, and clinical improvement was observed in approximately half of the fasudil hydrochloride infusions. Our findings suggested that the IAF therapy was safe and effective for patients with symptomatic vasospasm after subarachnoid hemorrhage.
影响因子：
4.1
作者：
HALEY, EC;KASSELL, NF;GERMANSON, TP
通讯作者：
GERMANSON, TP