Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study
Bilateral brain reorganization with memantine and constraint-induced aphasia therapy in chronic post-stroke aphasia: An ERP study
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DOI：
10.1016/j.bandl.2015.04.003
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发表时间：
2015-06-01
影响因子：
2.5
通讯作者：
Pablo Lara, J.
中科院分区：
文献类型：
--
作者：
Barbancho, Miguel A.;Berthier, Marcelo L.;Pablo Lara, J.
对28例慢性卒中后失语患者进行随机、双盲、安慰剂对照的美金刚和强迫性失语治疗(CAT)试验，观察静默阅读过程中事件相关电位(P100和N400)和均方根值(RMS)的变化。参与者单独接受美金刚/安慰剂治疗(0-16周)，然后接受药物联合CIAT治疗(16-18周)，然后单独接受美金刚/安慰剂治疗(18-20周)。美金金组的ERP/RMS值(第16周)比安慰剂组下降得更多。在应用CIAT期间(16-18周)，美金刚增强了失语症严重程度和ERP/RMS值的改善，并在此后(18-20周)保持稳定。ERP/RMS的变化发生在左右半球，并与语言成绩的提高相关。在两次单独的评估中，健康组的ERP/RMS均未发现变化。我们的结果表明，美金刚单独或联合CIAT诱导的失语症恢复受双侧皮层电位的影响。(C)2015 Elsevier Inc.保留所有权利。
Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials. (C) 2015 Elsevier Inc. All rights reserved.