The impact of ignoring inbreeding in pairwise kinship evaluations
The impact of ignoring inbreeding in pairwise kinship evaluations
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DOI：
10.1016/j.fsigss.2019.10.052
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发表时间：
2019-12-01
期刊：
影响因子：
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通讯作者：
Egeland, Thore
中科院分区：
文献类型：
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作者：
Brustad, Hilde Kjelgaard;Egeland, Thore
近亲交配在法医亲属关系推断中经常被忽视，要么是因为确切的家系未知，要么是因为目前的方法不适合近亲交配的家系。在许多情况下，这可能是一种合理的简化，但在其他情况下，它可能会导致对两个人之间的关联性的错误推断。为了量化忽略近亲繁殖的影响，我们模拟了一组近交系的标记数据，并使用标准的非自交系假设对它们进行成对亲属关系推断。
Inbreeding is often ignored in forensic kinship inference, either because the exact genealogies are unknown, or because current methods are inadequate for inbred pedigrees. In many situations, this may be a reasonable simplification, but in other, it can lead to wrong inference of relatedness between two individuals. In order to quantify the impact of ignoring inbreeding, we simulate marker data for a selection of inbred pedigrees, and subject them to pairwise kinship inference using standard noninbred assumptions.