MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease
MRI evaluation of the basal ganglia size and iron content in patients with Parkinson's disease
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DOI：
10.1007/s00415-005-0914-9
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发表时间：
2006-01-01
影响因子：
6
通讯作者：
Konitsiotis, S
中科院分区：
文献类型：
--
作者：
Kosta, P;Argyropoulou, MI;Konitsiotis, S
目的 通过 MRI 评估与帕金森病 (PD) 发病机制相关的基底节核的面积大小和铁积累程度。 方法 使用多回波 SE 序列 2000/20、40、60、80、100、120、1. 5 Tesla MR 成像仪对 40 例特发性 PD 患者和 40 例对照进行检查。 140、160（TR/TE）。评估 T2 弛豫时间 (T2) 以及黑质致密带 (SNc)、黑质网状带 (SNr)、壳核 (Pu)、苍白球外部 (GPe)、苍白球内部 (GPi)、尾状核 (CN)、蓝斑 (LC) 和丘脑底核 (STN) 的面积。与对照组相比，患者的 SNc (76. 8 +/- 6. 0) 较低，Pu (79.5 +/- 6.0) 和 GPe (69.5 +/- 7.0) 较高（分别为 78.6 +/- 3.8、77.4 +/- 3.9 和 67.3 +/- 5.7），p < 0.05。患者的 CN (125.9 +/- 20.2) 和 Pu (201.5 +/- 48.7) 面积高于对照组（分别为 110.7 +/- 21.5 和 180.1 +/- 41.1），p < 0.05。当单独评估患者受影响较大的一侧时，观察到 SNc 的 T2 (73.6 +/- 8.9) 下降更明显。与病程 >= 5 年的患者（分别为 75.8 +/- 10.9 和 190.9 +/- 41.0）相比，病程 > 5 年的患者 STN T2 (71.5 +/- 6.3) 较低，Pu 面积较高 (215.3 +/- 54.9)，p < 0.05。 结论 这些结果表明 PD 中基底神经节回路功能障碍不仅会影响 SNc 中的铁含量，还会影响 STN、Pu 和 GPe 中的铁含量。剩余多巴胺能纤维的代偿性出芽可以解释 CN 和 Pu 面积的增加。
Objective To evaluate by MRI the area size and the degree of iron accumulation in basal ganglia nuclei that are implicated in the pathogenesis of Parkinson's disease (PD).Methods 40 patients with idiopathic PD and 40 controls were examined on a 1. 5 Tesla MR imager, using a multiecho SE sequence 2000/20, 40, 60, 80, 100, 120, 140, 160 (TR/TE). The T2 relaxation time (T2) and the area of substantia nigra zona compacta (SNc), substantia nigra zona reticulata (SNr), putamen (Pu), globus pallidus external (GPe), globus pallidus internal (GPi), caudate nucleus (CN), locus coeruleus (LC) and subthalamic nucleus (STN) were assessed.Results The T2 of SNc (76. 8 +/- 6. 0) was lower and of Pu (79.5 +/- 6.0) and GPe (69.5 +/- 7.0) was higher in patients than in controls (78.6 +/- 3.8, 77.4 +/- 3.9 and 67.3 +/- 5.7, respectively), p < 0.05. The area of CN (125.9 +/- 20.2) and Pu (201.5 +/- 48.7) was higher in patients than in controls (110.7 +/- 21.5 and 180.1 +/- 41.1, respectively), p < 0.05. A more pronounced decrease in the T2 of SNc (73.6 +/- 8.9) was observed when the more affected side of patients was evaluated separately. In patients with disease duration > 5 years the T2 of STN (71.5 +/- 6.3) was lower and the area of Pu was higher (215.3 +/- 54.9) compared with those with disease duration >= 5 years (75.8 +/- 10.9 and 190.9 +/- 41.0 respectively), p < 0.05.Conclusions These findings suggest that dysfunction of the basal ganglia circuitry in PD may affect iron content not only in SNc but in STN, Pu and GPe as well. Compensatory sprouting of the remaining dopaminergic fibers could account for the increased area of the CN and Pu.