Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
Vitamin D and atopy and asthma phenotypes in children: a longitudinal cohort study
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DOI：
10.1183/09031936.00029011
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发表时间：
2011-12-01
影响因子：
24.3
通讯作者：
Holt, P. G.
中科院分区：
文献类型：
--
作者：
Hollams, E. M.;Hart, P. H.;Holt, P. G.
在一些研究中，维生素D与已确诊疾病的儿童中的特应性和哮喘相关表型有关，但其在社区水平疾病发病中的作用尚不清楚。本研究的目的是调查澳大利亚西澳珀斯（南纬32度）6岁和14岁儿童的维生素D状况与过敏和哮喘发生的生物学特征之间的关系。对989名6岁和1,380名14岁儿童的血清维生素D进行了测定，其中689名受试者在两个年龄段进行了评估。使用先前确定的表型数据，将维生素D水平作为两个年龄段呼吸和过敏结局的风险修正因子进行评估。6岁时维生素D水平对14岁时临床表型发展的预测价值也进行了检查。两个年龄段儿童的血清维生素D水平与并发过敏表型呈负相关;性别分层显示，这种关联主要限于男性。此外，6岁时的维生素D水平是随后的特应性/哮喘相关的表型在14岁时的显着predictors。在一个健康的社区设置，儿童（特别是男性）与不足的维生素D是在发展特应性，随后支气管高反应性（BHR）和哮喘的风险增加。在一个大的研究队列中，6岁和14岁时维生素D不足的男性有增加的特应性和BHR。6岁时低维生素D是14岁时特应性和哮喘的预测因子。
Vitamin D has been linked in some studies with atopy - and asthma-associated phenotypes in children with established disease, but its role in disease inception at the community level is less clear. The aim of the present study was to investigate associations between vitamin D status and biological signatures indicative of allergy and asthma development in children aged 6 and 14 years in Perth, WA, Australia (latitude 32 degrees S).Serum vitamin D was assayed in 989 6-yr-olds and 1,380 14-yr-olds from an unselected community birth cohort; 689 subjects were assessed at both ages. Vitamin D levels were assessed as a risk modifier for respiratory and allergic outcomes at both ages, using previously ascertained phenotypic data. The predictive value of vitamin D levels at age 6 yrs for development of clinical phenotypes at age 14 yrs was also examined.Serum vitamin D levels in children of both ages were negatively associated with concurrent allergic phenotypes; sex stratification revealed that this association was restricted mainly to males. Furthermore, vitamin D levels at age 6 yrs were significant predictors of subsequent atopy/asthma-associated phenotypes at age 14 yrs.In an unselected community setting, children (particularly males) with inadequate vitamin D are at increased risk of developing atopy, and subsequently bronchial hyperresponsiveness (BHR) and asthma. In a large unselected cohort, males with inadequate vitamin D at 6 and 14 yrs of age had increased atopy and BHR. Low vitamin D at age 6 yrs was a predictor of atopy and asthma at 14 yrs of age.