Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals.
Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals.
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DOI：
10.4049/jimmunol.0804224
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发表时间：
2009-05-15
期刊：
影响因子：
--
通讯作者：
Riley EM
中科院分区：
文献类型：
--
作者：
Korbel DS;Norman PJ;Newman KC;Horowitz A;Gendzekhadze K;Parham P;Riley EM
自然杀伤 (NK) 细胞产生的 IFN-γ 是抵抗感染的先天防御的重要组成部分。在这里，我们证明，在用多种微生物配体体外刺激人外周血 NK 细胞后，CD56dim 以及 CD56bright NK 细胞有助于整体 NK 细胞 IFN-γ 反应，对于大多数细胞供体而言，IFN-γ+ CD56dim NK 细胞数量超过 IFN-γ+ CD56bright NK 细胞。我们还观察到，人类 NK IFN-γ 对微生物配体的反应程度因个体而异。 CD56bright（而非 CD56dim）NK 细胞的抗菌反应与骨髓辅助细胞的抗菌反应高度相关；微生物刺激后 IFN-γ+ CD56dim 与 IFN-γ+ CD56bright NK 细胞的比率在个体之间有所不同，但对于给定的供体来说随着时间的推移保持恒定。此外，IFN-γ+ CD56dim 与 IFN-γ+ CD56bright NK 细胞对不同微生物刺激的比率高度相关，并且 CD56dim 和 CD56bright NK 细胞的相对反应与杀伤性免疫球蛋白样受体 (KIR) 基因型高度显着相关。这些数据揭示了 KIR 基因型对 NK 细胞响应非病毒感染的能力的影响（可能通过 NK 细胞许可介导），并对人类感染易感性的遗传调控具有影响。
IFN-γ emanating from natural killer (NK) cells is an important component of innate defence against infection. Here we demonstrate that, following in vitro stimulation of human peripheral blood NK cells with a variety of microbial ligands, CD56dim as well as CD56bright NK cells contribute to the overall NK cell IFN-γ response with, for most cell donors, IFN-γ+ CD56dim NK cells outnumbering IFN-γ+ CD56bright NK cells. We also observe that the magnitude of the human NK IFN-γ response to microbial ligands varies between individuals; that the antimicrobial response of CD56bright, but not CD56dim, NK cells is highly correlated with that of myeloid accessory cells; and that the ratio of IFN-γ+ CD56dim to IFN-γ+ CD56bright NK cells following microbial stimulation differs between individuals but remains constant for a given donor over time. Furthermore, ratios of IFN-γ+ CD56dim to IFN-γ+ CD56bright NK cells for different microbial stimuli are highly correlated and the relative response of CD56dim and CD56bright NK cells is highly significantly associated with killer immunoglobulin-like receptor (KIR) genotype. These data reveal an influence of KIR genotype, possibly mediated via NK cell licensing, on the ability of NK cells to respond to non-viral infections and have implications for genetic regulation of susceptibility to infection in humans.
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影响因子：
3.2
作者：
Middleton, D.;Meenagh, A.;Gourraud, P. A.
通讯作者：
Gourraud, P. A.
影响因子：
4.4
作者：
Almeida, Catarina R.;Davis, Daniel M.
通讯作者：
Davis, Daniel M.
DOI：
10.1084/jem.20052507
发表时间：
2006-04-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Freud AG;Yokohama A;Becknell B;Lee MT;Mao HC;Ferketich AK;Caligiuri MA
通讯作者：
Caligiuri MA
影响因子：
4.4
作者：
Artavanis-Tsakonas, K;Eleme, K;Riley, EM
通讯作者：
Riley, EM
影响因子：
15.3
作者：
Davis, DM;Mandelboim, O;Strominger, JL
通讯作者：
Strominger, JL