N-back working memory paradigm: A meta-analysis of normative functional neuroimaging
N-back working memory paradigm: A meta-analysis of normative functional neuroimaging
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DOI：
10.1002/hbm.20131
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发表时间：
2005-05-01
影响因子：
4.8
通讯作者：
Bullmore, ET
中科院分区：
文献类型：
--
作者：
Owen, AM;McMillan, KM;Bullmore, ET
对工作记忆的功能性神经影像学研究的最流行的实验范例之一一直是N背任务，其中要求受试者监测一系列言语或非语言刺激的身份或位置，并指出何时当前呈现的刺激是何时是与以前提出的N试验相同。我们对24个主要的N-BACK任务变体的主要研究（位置监测与身份监测）和工作记忆的内容（言语或非语言）进行了24项主要研究，对TALAIRACH空间中的668组激活坐标进行了定量荟萃分析。我们发现以下皮层区域是鲁棒激活的（voxelwise的错误发现率= 1％）：侧向前前皮层；背扣带和内侧前皮层；背外侧和腹侧前额叶皮层；额叶；以及内侧和侧后顶叶皮层。基于原始数据的适当子集的子公司荟萃分析显示出广泛相似的激活模式，用于监测言语刺激以及非语言刺激的位置和身份监测。还有一些证据表明，响应不同的任务变体的不同额叶激活模式。讨论了通用大规模额叶系统中每个主要的皮质成分的功能专业。我们得出的结论是，定量荟萃分析也可能是一种有力的]，用于结合Talairach空间中报道的多项主要研究的结果。在这里，它提供了通过各种版本的n折工作记忆范式以及通过工作记忆来广泛一致地激活额叶和顶叶皮质区域的广泛激活。 （c）2005 Wiley-Liss，Inc。
One of the most popular experimental paradigms for functional neuroimaging studies of working memory has been the n-back task, in which subjects are asked to monitor the identity or location of a series of verbal or nonverbal stimuli and to indicate when the currently presented stimulus is the same as the one presented n trials previously. We conducted a quantitative meta-analysis of 668 sets of activation coordinates in Talairach space reported in 24 primary studies of n-back task variants manipulating process (location vs. identity monitoring) and content (verbal or nonverbal) of working memory. We found the following cortical regions were activated robustly (voxelwise false discovery rate = 1%): lateral premotor cortex; dorsal cingulate and medial premotor cortex; dorsolateral and ventrolateral prefrontal cortex; frontal poles; and medial and lateral posterior parietal cortex. Subsidiary meta-analyses based on appropriate subsets of the primary data demonstrated broadly similar activation patterns for identity monitoring of verbal stimuli and both location and identity monitoring of nonverbal stimuli. There was also some evidence for distinct frontoparietal activation patterns in response to different task variants. The functional specializations of each of the major cortical components in the generic large-scale frontoparietal system are discussed. We conclude that quantitative meta-analysis can be a powerful too] for combining results of multiple primary studies reported in Talairach space. Here, it provides evidence both for broadly consistent activation of frontal and parietal cortical regions by various versions of the n-back working memory paradigm, and for process- and content-specific frontoparietal activation by working memory. (c) 2005 Wiley-Liss, Inc.