Liver fibrosis: Noninvasive diagnosis with double contrast material-enhanced MR imaging
Liver fibrosis: Noninvasive diagnosis with double contrast material-enhanced MR imaging
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DOI：
10.1148/radiol.2392050505
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发表时间：
2006-05-01
期刊：
影响因子：
19.7
通讯作者：
Sirlin, CB
中科院分区：
文献类型：
--
作者：
Aguirre, DA;Behling, CA;Sirlin, CB
目的：回顾性评价双对比材料增强（以下简称双增强）磁共振（MR）成像描述肝纤维化的准确性，与组织病理学分析结果作为参考standard.Materials和方法：机构审查委员会批准了这一符合健康保险责任法案的研究，并放弃了知情同意的要求。在2001年至2004年期间，101例患者（58例男性，43例女性;平均年龄+/-标准差，52岁+/- 10）接受了超顺磁性氧化铁（SPIO）增强和双增强破坏梯度回波（SPGR）序列的双增强MR成像，并具有诊断肝纤维化的可靠参考标准。两名不知情的MR放射科医生回顾性地对MR图像上的肝脏纹理特征进行定性（网状化、结节化和总评分）和定量（高信号和低信号肝脏区域之间的对比噪声比、变异系数和噪声校正变异系数）评分。晚期患者（METAVIR纤维化评分>= 3）与轻度患者（METAVIR评分>= 3）的图像评分
Purpose: To retrospectively evaluate the accuracy of double contrast material-enhanced (hereafter double-enhanced) magnetic resonance (MR) imaging depiction of hepatic fibrosis, with histopathologic analysis findings as the reference standard.Materials and Methods: The institutional review board approved this HIPAA-compliant study and waived the requirement for informed consent. One hundred one patients (58 men, 43 women; mean age +/- standard deviation, 52 years +/- 10) who underwent double- enhanced MR imaging with superparamagnetic iron oxide (SPIO)-enhanced and double- enhanced spoiled gradient-echo (SPGR) sequences between 2001 and 2004 and had a reliable reference standard for the diagnosis of liver fibrosis were included. Two blinded MR radiologists retrospectively scored qualitative (reticulation, nodularity, and total scores) and quantitative (contrast-to- noise ratio between hyperintense and hypointense liver regions, coefficient of variation, and noise-corrected coefficient of variation) liver texture features on MR images in consensus. The image scores for patients with advanced (METAVIR fibrosis score >= 3) versus those for patients with mild ( METAVIR score