Time-Varied Characteristics of Acupuncture Effects in fMRI Studies
Time-Varied Characteristics of Acupuncture Effects in fMRI Studies
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fMRI 研究中针灸效果的时变特征
DOI：
10.1002/hbm.20769
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发表时间：
2009-11-01
影响因子：
4.8
通讯作者：
Liu, Yijun
中科院分区：
文献类型：
--
作者：
Bai, Lijun;Qin, Wei;Liu, Yijun
在用区组设计的实验范式研究针刺引起的神经反应时，一般线性模型（GLM）预测的针刺神经反应的时间动力学在有限的实验操作时间内符合典型的“开-关”变化。尽管缺乏直接的证据关联其心理生理反应，许多临床报告表明，针灸可以提供疼痛缓解超越针刺会议。因此，一个典型的GLM分析可能是不敏感的或不适当的识别由针灸引起的神经反应的改变。我们开发了一种新的方法来研究针灸持续效应的动力学基础。具体来说，我们设计了两个独立的模型来评估基线活动（刺激前）和神经活动在连续的时期，使用三个块设计的功能运行：在穴位ST 36，非经络点（NMP）刺激，和视觉任务的针灸。我们发现，在休息期间的活动模式与刺激类型，休息活动可能甚至高于刺激阶段。在休息期间的活动升高的这种影响可以减少或消除在刺激条件期间的活动，或者甚至使用常规GLM分析来逆转大脑激活的迹象。此外，这种持续的反应，然后在ST 36和NMP针刺，表现出不同的模式，在广泛的大脑结构，特别是在边缘系统和脑干。这些发现可能对一系列针灸神经影像学研究的设计和解释产生重大影响。《脑图谱》30：3445-3460，2009年。(C)2009 Wiley-Liss，Inc.
When studying the neural responses to acupuncture with a block-designed paradigm, its temporal dynamics predicted by the general linear model (GLM) conforms to typical "on-off" variations during a limited period of the experiment manipulation. Despite a lack of direct evidence associating its psychophysiological response, numerous clinical reports suggest that acupuncture can provide pain relief beyond a needling session. Therefore, a typical GLM analysis may be insensitive or inappropriate for identifying altered neural responses resulting from acupuncture. We developed a new approach to investigate the dynamics underlying sustained effects of acupuncture. Specifically, we designed two separate models to evaluate the baseline activities (prior to stimulation) and neural activities in sequential epochs, using three block-designed functional runs: acupuncture at acupoint ST36, nonmeridian point (NMP) stimulation, and a visual task. We found that the activity patterns during rest were associated with the stimulus types and that the resting activities might be even higher than that of stimulation phases. Such effects of the elevated activity during rest may reduce or eliminate the activity during stimulus conditions or even reverse the sign of brain activation using conventional GLM analysis. Moreover, such sustained responses, followed by acupuncture at ST36 and NMP, exhibited distinct patterns in wide brain structures, particularly in the limbic system and brainstem. These findings may pose great implications for the design and interpretation of a range of acupuncture neuroimaging studies. Hum Brain Mapp 30:3445-3460, 2009. (C) 2009 Wiley-Liss, Inc.