In vivo sites and cellular mechanisms of T reg cell-mediated suppression.
In vivo sites and cellular mechanisms of T reg cell-mediated suppression.
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DOI：
10.1084/jem.20060214
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发表时间：
2006-03-20
影响因子：
15.3
通讯作者：
Campbell, Daniel J
中科院分区：
文献类型：
--
作者：
Rudensky, Alexander Y;Campbell, Daniel J
调节性CD4 T（T reg）细胞控制对自身抗原和病原体的免疫应答。然而，T reg细胞在体内何处起作用以减少效应T细胞以及T reg细胞靶向效应T细胞活化或分化的哪个阶段仍然未知。此外，尚未确定体内直接效应T细胞-T reg细胞接触的要求。几项新的研究对这些重要问题提供了不同的答案。
Regulatory CD4 T (T reg) cells control immune responses to self-antigens and pathogens. However, where T reg cells act to curtail effector T cells in vivo and what stage of effector T cell activation or differentiation is targeted by T reg cells remain unknown. Furthermore, a requirement for direct effector T cell–T reg cell contact in vivo has not been ascertained. Varying answers to these important questions have been provided by several new studies.