Olfactory drug delivery with intranasal sprays after nasal midvault reconstruction.
Olfactory drug delivery with intranasal sprays after nasal midvault reconstruction.
复制标题
鼻中拱重建后鼻内喷雾的嗅觉药物输送。
DOI：
10.1016/j.ijpharm.2023.123341
复制
发表时间：
2023
影响因子：
5.8
通讯作者：
Frank-Ito,DennisO
中科院分区：
文献类型：
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作者：
Chiang,Harry;Martin,HannahL;Sicard,RyanM;Frank-Ito,DennisO
传导性嗅觉和鼻-脑药物递送是重要的过程，其仍然受到气味剂或药物递送到嗅觉空间不足的限制。主要的挑战包括解剖学障碍和嗅觉区域的靶向性差。本研究使用计算流体动力学来研究鼻腔中穹窿手术对鼻内喷雾的嗅觉药物递送的影响。在两具新鲜尸体标本上进行软组织提升、扩张皮瓣和扩张移植，使用计算机断层扫描进行气道重建。在以下条件下进行鼻气流和药物颗粒转运模拟：吸入速率（15、30 L/min）、喷雾速度（1、5、10 m/s）、喷雾位置（顶部、底部、中心、内侧、外侧）、头部位置（直立、仰卧、向前、向后）和粒度（1-100 µm）。模拟结果被用来计算药物颗粒沉积到嗅气隙和嗅球。总的嗅觉沉积< 5%，但当按粒径分类时达到最大值36.33%。鼻中穹窿手术和嗅觉沉积之间没有关联。没有单一的参数或技术表现出上级嗅觉沉积，但较小的粒径，较慢的喷雾速度，和较高的吸入速率往往优化嗅觉沉积，提供了重要的影响，为未来的鼻内喷雾和药物设计，以目标嗅觉空间。
Conductive olfaction and nose to brain drug delivery are important processes that remain limited by inadequate odorant or drug delivery to the olfactory airspace. Primary challenges include anatomic barriers and poor targeting to the olfactory region. This study uses computational fluid dynamics to investigate the effects of nasal midvault surgery on olfactory drug delivery with intranasal sprays. Soft tissue elevation, spreader flaps, and spreader grafts were performed on two fresh cadaveric specimens, using computed tomography for airway reconstruction. Nasal airflow and drug particle transport simulations were performed under these conditions: inhalation rate (15, 30 L/min), spray velocity (1, 5, 10 m/s), spray location (top, bottom, center, medial, lateral), head position (upright, supine, forward, backward), and particle size (1–100 µm). Simulation results were used to calculate drug particle deposition to the olfactory airspaces and bulbs. Total olfactory deposition was < 5% but attained a maximum of 36.33% when sorted by particle size. There was no association between nasal midvault surgery and olfactory deposition. No single parameter or technique demonstrated superior olfactory deposition, but smaller particle size, slower spray velocity, and higher inhalation rate tended to optimize olfactory deposition, providing important implications for future intranasal spray and drug design to target the olfactory airspace.