Lack of prognostic significance of prostate biopsies in metastatic androgen independent prostate cancer.
Lack of prognostic significance of prostate biopsies in metastatic androgen independent prostate cancer.
复制标题
前列腺活检在转移性雄激素非依赖性前列腺癌中缺乏预后意义。
DOI：
10.1111/j.1464-410x.2007.07173.x
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发表时间：
2007
影响因子：
4.5
通讯作者：
Figg,WilliamD
中科院分区：
文献类型：
--
作者：
Aragon-Ching,JeannyB;Gillespie,John;Price,DouglasK;Chuaqui,Rodrigo;Rodriguez-Canales,Jaime;Steinberg,SethM;Dahut,WilliamL;Figg,WilliamD
[目的]探讨转移性雄激素非依赖性前列腺癌(AIPC)患者前列腺体内存活肿瘤的意义。方法和方法对40例经直肠前列腺活检的转移性AIPC患者的临床病理特征进行分析。结果40例患者中有19例(48%)前列腺活检显示肿瘤存活。在接受放射治疗(RT)的18名患者中，9名患者的研究中活检结果为阴性。既往放疗病史与活检阳性肿瘤患者的总存活率无关(P= 0.84)。此外，在这40例患者中，活检阳性或阴性与总生存期(OS)之间没有统计学意义的相关性(P= 0.39)，活检阴性患者的中位OS为19.6 月，活检阳性患者为19.8 月。既往的放射治疗病史与前列腺活检阴性无关；后者似乎对预后没有影响。
OBJECTIVETo assess the significance of viable tumour in the prostate of patients with metastatic androgen‐independent prostate cancer (AIPC).PATIENTS AND METHODSWe evaluated the clinicopathological features, including follow‐up, of 40 men with metastatic AIPC who had a transrectal biopsy of the prostate.RESULTSProstate biopsies (median three cores per biopsy) showed viable tumour in 19 of 40 patients (48%). Of the 18 patients who had received radiotherapy (RT), nine had negative on‐study biopsy results. A previous history of RT was not associated with overall survival in patients with biopsy‐positive tumours (P= 0.84). Also, there was no statistically significant association between positive or negative biopsy status and overall survival (OS) in these 40 patients (P= 0.39), with a similar median OS of 19.6 months for biopsy‐negative and 19.8 months for biopsy‐positive patients, respectively.CONCLUSIONSTaking prostate biopsies at the time of documented metastatic AIPC yielded tumour in about half the patients. A previous history of RT was not associated with a negative prostate biopsy; the latter appears to have no influence on the prognosis.