Forty years on: clathrin-coated pits continue to fascinate.
Forty years on: clathrin-coated pits continue to fascinate.
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DOI：
10.1091/mbc.e16-04-0213
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发表时间：
2017-04-01
影响因子：
3.3
通讯作者：
Ayscough K
中科院分区：
文献类型：
--
作者：
Maib H;Smythe E;Ayscough K
网格蛋白介导的内吞作用（CME）是细胞生物学中的一个基本过程，在过去的几十年中得到了广泛的研究。每一个细胞生物学家在他或她的教育过程中的某个时候都会学习到它，这个过程的美丽让我们中的许多人更深入，并使其成为我们研究的主题。对CME机制的研究已经取得了很大的进展，并且该领域正变得越来越复杂，每年都有数百篇新的出版物。这使得人们很容易迷失在大量的文献中，忘记了该领域的基本原理，这些基本原理是基于对40多年前的简单观察的仔细解释，安德森、布朗和戈尔茨坦在1977年进行的一项研究就是例证。我们研究了这项开创性的研究如何对我们理解CME及其在过去四十年中不断增长的复杂性起到关键作用。
Clathrin-mediated endocytosis (CME) is a fundamental process in cell biology and has been extensively investigated over the past several decades. Every cell biologist learns about it at some point during his or her education, and the beauty of this process has led many of us to go deeper and make it the topic of our research. Great progress has been made toward elucidating the mechanisms of CME, and the field is becoming increasingly complex, with several hundred new publications every year. This makes it easy to get lost in the vast amount of literature and forget about the fundamentals of the field, which are based on the careful interpretation of simple observations made >40 years ago, as exemplified by a study performed by Anderson, Brown, and Goldstein in 1977. We examine how this seminal study was pivotal to our understanding of CME and its progression into ever-increasing complexity over the past four decades.