Skin-Patchable Electromagnetic Biosensors for Noninvasive and Wireless Glucose Monitoring
Skin-Patchable Electromagnetic Biosensors for Noninvasive and Wireless Glucose Monitoring
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DOI：
10.1109/led.2024.3369623
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发表时间：
2024-05
影响因子：
4.9
通讯作者：
Qian Wang;Guang Yao;Wenhao Lou;Fan Li;Tianyao Zhang;Sihong Chen;Maowen Xie;Mengyao Yuan;Kangning Zhao;T. Pan;Min Gao;Yuan Lin
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文献类型：
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作者：
Qian Wang;Guang Yao;Wenhao Lou;Fan Li;Tianyao Zhang;Sihong Chen;Maowen Xie;Mengyao Yuan;Kangning Zhao;T. Pan;Min Gao;Yuan Lin
监测血糖浓度对于诊断和预测临床糖尿病进展至关重要。然而，静脉穿刺采集的血液的侵入和替代生物液体的信息延迟不可避免地影响动态和准确的监测。在这里，我们提出了一个皮肤patchable，非侵入性，无线血糖生物传感系统组成的一个灵活的电磁谐振电路和无线数据采集单元，相关的S参数的变化和葡萄糖水平诱导血液介电特性的改变。离体和志愿者低血糖至高血糖监测验证实现了超高的保真度和相关性，具有> 0.0626°/（mg/dl）的高灵敏度。离体哺乳动物皮肤和健康志愿者口服葡萄糖耐量试验的相关系数值分别为0.996和0.945，与商业血糖仪相当。新兴的无创和无线模式将努力弥合最小的不适和可靠的测量之间的差距，刺激这种便携式血糖监测系统的广泛采用。
Monitoring blood glucose concentration is crucial in diagnosing and predicting clinical diabetes progression. However, the invasion of blood sampled by venipuncture and the informative delay of alternative biofluids inevitably affect dynamic and accurate monitoring. Here, we proposed a skin-patchable, noninvasive, and wireless blood glucose biosensing system composed of a flexible electromagnetic resonant circuit and a wireless data acquisition unit, correlating the S parameter shifts and glucose level-inducing blood dielectric property alteration. Ex vivo and volunteer hypo- to hyperglycemic monitoring validations achieved supered fidelity and correlation with high sensitivity > 0.0626°/(mg/dl). The correlation coefficient values were 0.996 and 0.945 for ex vivo mammalian skin and healthy volunteers’ oral glucose tolerance tests, comparable to commercial blood glucose meters. Emerging noninvasive and wireless modalities would strive to bridge gaps between minimal discomfort and reliable measurements, spurring the widespread adoption of this portable blood glucose monitoring system.