INTERACTIONS OF INGESTED FOOD, BEVERAGE, AND TOBACCO COMPONENTS INVOLVING HUMAN CYTOCHROME P4501A2, 2A6, 2E1, AND 3A4 ENZYMES
INTERACTIONS OF INGESTED FOOD, BEVERAGE, AND TOBACCO COMPONENTS INVOLVING HUMAN CYTOCHROME P4501A2, 2A6, 2E1, AND 3A4 ENZYMES
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DOI：
10.1289/ehp.94102s949
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发表时间：
1994-11-01
影响因子：
10.4
通讯作者：
HARRIS, TM
中科院分区：
文献类型：
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作者：
GUENGERICH, FP;SHIMADA, T;HARRIS, TM
人类细胞色素P450 （P450）酶参与食品、饮料和烟草制品中天然产物的氧化，其催化活性也可由材料成分调节。黄曲霉毒素B-1微粒体对8,9-环氧外显子的激活是由黄酮和7,8-苯并黄酮刺激的，而被柚皮素（葡萄柚的主要成分）类黄酮减弱。P4502E1已被证明在激活一些非常低分子量的癌症嫌疑人中发挥潜在的主要作用，包括氨基甲酸乙酯（脲聚糖），它存在于酒精饮料中，特别是石白兰地。这种酶（P4502E1）也可以被乙醇诱导。烟草含有大量潜在的致癌物。在人肝微粒体中，P4501A2在香烟烟雾凝聚物的激活中发挥了重要作用。一些遗传毒性可能是由于芳胺。P4501A2也受到粗烟烟气冷凝物成分的抑制。烟草特有的亚硝胺被一些P450酶激活。在已知存在于人类肝脏中的亚硝胺中，P4501A2、2A6和2E1可以激活这些亚硝胺产生遗传毒性产物。
Human cytochrome P450 (P450) enzymes are involved in the oxidation of natural products found in foods, beverages, and tobacco products and their catalytic activities can also be modulated by components of the materials. The microsomal activation of aflatoxin B-1 to the exo-8,9-epoxide is stimulated by flavone and 7,8-benzoflavone, and attenuated by the flavonoid naringenin, a major component of grapefruit. P4502E1 has been demonstrated to play a potentially major role in the activation of a number of very low-molecular weight cancer suspects, including ethyl carbamate (urethan), which is present in alcoholic beverages and particularly stone brandies. The enzyme (P4502E1) is also known to be inducible by ethanol. Tobacco contains a large number of potential carcinogens. In human liver microsomes a significant role for P4501A2 can be demonstrated in the activation of cigarette smoke condensate. Some of the genotoxicity may be due to arylamines. P4501A2 is also inhibited by components of crude cigarette smoke condensate. The tobacco-specific nitrosamines are activated by a number of P450 enzymes. Of those known to be present in human liver, P4501A2, 2A6, and 2E1 can activate these nitrosamines to genotoxic products.