Control of jejunal sucrase and maltase activity by dietary sucrose or fructose in man. A model for the study of enzyme regulation in man.
Control of jejunal sucrase and maltase activity by dietary sucrose or fructose in man. A model for the study of enzyme regulation in man.
复制标题
通过膳食蔗糖或果糖控制人体空肠蔗糖酶和麦芽糖酶活性。
DOI：
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发表时间：
1968
影响因子：
15.9
通讯作者：
R. Herman
中科院分区：
文献类型：
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作者：
N. Rosensweig;R. Herman
在7名正常非禁食男性志愿者中研究了膳食糖对空肠二磷酸脱氢酶活性的具体影响。测试的糖是蔗糖、麦芽糖、乳糖、葡萄糖、果糖和半乳糖。比较了每种糖在等热量流质饮食中的作用。在所有受试者中，与葡萄糖喂养相比，蔗糖喂养显著增加了空肠蔗糖酶（S）和麦芽糖酶（M）的活性，但乳糖酶（L）的活性没有增加。S/L和M/L比值显著增加。在两个受试者中，果糖喂养在比较果糖和葡萄糖饮食时给出了与蔗糖相似的结果。1例受试者喂食乳糖、半乳糖和麦芽糖。与葡萄糖相比，这些糖并不增加二硫代磷酸酶的活性。果糖似乎是蔗糖分子中的活性成分。这些结果表明，特定的膳食糖可以改变酶的活性在人的小肠以特定的方式。蔗糖和果糖能够调节蔗糖酶和麦芽糖酶的活性。肠道酶的饮食改变可能是研究人类酶活性调节的合适系统。
The specific effect of dietary sugars on jejunal disaccharidase activity in seven normal nonfasted male volunteers was studied. The sugars tested were sucrose, maltose, lactose, glucose, fructose, and galactose. Comparisons were made of the effects of each sugar in an isocaloric liquid diet. In all subjects, sucrose feeding, as compared to glucose feeding, significantly increased jejunal sucrase (S) and maltase (M) activities, but not lactase (L) activity. The S/L and M/L ratios increased to a significant degree. Fructose feeding, in two subjects, gave results similar to sucrose when comparing fructose and glucose diets. One subject was fed lactose, galactose, and maltose. These sugars, compared to glucose, did not increase disaccharidase activity. Fructose appears to be the active principle in the sucrose molecule. These results demonstrate that specific dietary sugars can alter enzyme activity in the small intestine of man in a specific fashion. Sucrose and fructose are able to regulate sucrase and maltase activity. Dietary alteration of intestinal enzymes may represent a suitable system for studying the regulation of enzyme activity in man.