Optical phase conjugation for turbidity suppression in biological samples
Optical phase conjugation for turbidity suppression in biological samples
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DOI：
10.1038/nphoton.2007.297
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发表时间：
2008-02-01
期刊：
影响因子：
35
通讯作者：
Yang, Changhuei
中科院分区：
文献类型：
--
作者：
Yaqoob, Zahid;Psaltis, Demetri;Yang, Changhuei
弹性光散射是生物组织中主要的光相互作用过程，它阻止了组织的透明。虽然散射可能看起来是随机的，但实际上它本质上是确定性的。我们表明，尽管实验的缺陷，光学相位共轭（λ = 532 nm）可以迫使传输的光场通过生物靶折回其轨迹，并恢复原来的光场。对于0.69 mm厚的鸡胸组织切片，我们可以将点源光返回增强约5 x 10（3）倍，并在29度的收集角内实现3.8的光透射增强因子。此外，我们发现，重建的质量，测量重建点源的宽度，是独立的组织厚度（厚度为0.69毫米）。这种现象可用于增强通过组织的光透射，使得能够测量小的组织运动，并形成新的组织成像技术的基础。
Elastic optical scattering, the dominant light-interaction process in biological tissues, prevents tissues from being transparent. Although scattering may appear stochastic, it is in fact deterministic in nature. We show that, despite experimental imperfections, optical phase conjugation (lambda = 532 nm) can force a transmitted light field to retrace its trajectory through a biological target and recover the original light field. For a 0.69-mm-thick chicken breast tissue section, we can enhance point-source light return by a factor of similar to 5 x 10(3) and achieve a light transmission enhancement factor of 3.8 within a collection angle of 29 degrees. Additionally, we find that the reconstruction's quality, measured by the width of the reconstructed point source, is independent of tissue thickness (up to a thickness of 0.69 mm). This phenomenon may be used to enhance light transmission through tissue, enable measurement of small tissue movements, and form the basis of new tissue imaging techniques.