GenBank.
GenBank.
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DOI：
10.1093/nar/gkw1070
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发表时间：
2017-01-04
影响因子：
14.9
通讯作者：
Sayers EW
中科院分区：
文献类型：
--
作者：
Benson DA;Cavanaugh M;Clark K;Karsch-Mizrachi I;Lipman DJ;Ostell J;Sayers EW
GenBank®（www.ncbi.nlm.nih.gov/genbank/）是一个综合性数据库，包含370 000种正式描述的物种的公开可用的核苷酸序列。这些序列主要通过单个实验室提交的资料和大规模测序项目（包括全基因组鸟枪测序项目和环境采样项目）的批量提交资料获得。大多数提交是使用基于网络的BankIt或NCBI提交门户网站。GenBank工作人员在收到数据后分配登录号。与欧洲核苷酸档案馆（ENA）和日本DNA数据库（DDBJ）的每日数据交换确保了全球范围的覆盖。GenBank可通过NCBI核苷酸数据库访问，该数据库链接到相关信息，如分类学，基因组，蛋白质序列和结构，以及PubMed中的生物医学期刊文献。BLAST提供GenBank和其他序列数据库的序列相似性检索。基因库数据库的完整双月发布和每日更新可通过FTP获得。最近的更新包括关于序列标识符的政策的变化，改进的16 S提交向导，靶向基因座研究，提交甲基化和BioNano映射文件的能力，以及抗微生物耐药基因数据库。
GenBank® (www.ncbi.nlm.nih.gov/genbank/) is a comprehensive database that contains publicly available nucleotide sequences for 370 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole genome shotgun (WGS) and environmental sampling projects. Most submissions are made using the web-based BankIt or the NCBI Submission Portal. GenBank staff assign accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive (ENA) and the DNA Data Bank of Japan (DDBJ) ensures worldwide coverage. GenBank is accessible through the NCBI Nucleotide database, which links to related information such as taxonomy, genomes, protein sequences and structures, and biomedical journal literature in PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP. Recent updates include changes to policies regarding sequence identifiers, an improved 16S submission wizard, targeted loci studies, the ability to submit methylation and BioNano mapping files, and a database of anti-microbial resistance genes.