Wireless Batteryless Implantable Blood Pressure Monitoring Microsystem for Small Laboratory Animals
Wireless Batteryless Implantable Blood Pressure Monitoring Microsystem for Small Laboratory Animals
复制标题
DOI：
10.1109/jsen.2009.2030982
复制
发表时间：
2010-02-01
影响因子：
4.3
通讯作者：
Young, Darrin J.
中科院分区：
文献类型：
--
作者：
Cong, Peng;Ko, Wen H.;Young, Darrin J.
一种用于小型实验动物的新型无线、无电池、植入式血压监测微系统是为先进的生物和系统生物学研究而开发的。该系统采用仪器化的弹性圆形袖带，包裹在血管上，用于实时血压监测。弹性圆形袖带由柔软的生物相容性硅胶材料制成，内部填充生物相容性绝缘液，并配有浸入式微机电系统（MEMS）压力传感器和集成电子系统，可检测缩小的血管血压波形。该技术避免了血管穿透，并由于柔软的袖带弹性而大大减少了血管限制，因此对于长期监测很有吸引力。首先开发了大型模型工程实验来验证和演示该概念。然后制作一个微型原型监测袖带并将其植入两只实验室老鼠体内以评估其功能。然后将无线无电池监测微系统植入实验室大鼠并对其进行表征。微系统测量的体内血压波形与商用导管尖端传感器记录的参考波形在形状上与恒定比例因子紧密匹配，表明植入式监测微系统可以无线获得高保真度的血压信号。整个植入物耗散 300 μW，由外部自适应射频电源供电。
A novel, wireless, batteryless, implantable blood pressure monitoring microsystem for small laboratory animals is developed for advanced biological and system biology research. The system employs an instrumented elastic circular cuff, wrapped around a blood vessel, for real-time blood pressure monitoring. The elastic circular cuff is made of soft bio-compatible silicone material, which is filled with bio-compatible insulating fluid with an immersed microelectromechanical systems (MEMS) pressure sensor and integrated electronic system to detect a down-scaled vessel blood pressure waveform. This technique avoids vessel penetration and substantially minimizes vessel restriction due to the soft cuff elasticity, thus attractive for long-term monitoring. A large-model engineering experiment is first developed to verify and demonstrate the concept. A miniature prototype monitoring cuff is then fabricated and implanted in two laboratory rats to evaluate its functionality. A wireless and batteryless monitoring microsystem is then implanted and characterized in a laboratory rat. The measured in vivo blood pressure waveform by the microsystem and a reference waveform recorded by a commercial catheter-tip transducer are closely matched in shape with a constant scaling factor, demonstrating a blood pressure signal with high fidelity can be wirelessly obtained by the implantable monitoring microsystem. The overall implant dissipates 300 mu W, which is powered by an external adaptive RF powering source.